Early midcell localization of Escherichia coli PBP4 supports the function of peptidoglycan amidases
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010222
Abstract: Insertion of new material into the Escherichia coli peptidoglycan (PG) sacculus between the cytoplasmic membrane and the outer membrane requires a well-organized balance between synthetic and hydrolytic activities to maintain cell shape and avoid lysis.… read more here.
Keywords: escherichia coli; pbp4; function; midcell localization ... See more keywords
Recognition of peptidoglycan fragments by the transpeptidase PBP4 from Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.2210/pdb6dz8/pdb
Abstract: Peptidoglycan (PG) is an essential component of the cell envelope, maintaining bacterial cell shape and protecting it from bursting due to turgor pressure. The monoderm bacterium Staphylococcus aureus has a highly cross-linked PG, with ~90%… read more here.
Keywords: staphylococcus aureus; activity; peptide stems; pbp4 ... See more keywords
Impact of PBP4 Alterations on β-Lactam Resistance and Ceftobiprole Non-Susceptibility Among Enterococcus faecalis Clinical Isolates
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.816657
Abstract: Penicillin-resistance among Enterococcus faecalis clinical isolates has been recently associated with overexpression or aminoacidic substitutions in low-affinity PBP4. Ceftobiprole (BPR), a new-generation cephalosporin, is a therapeutic option against E. faecalis. Here, we present evidence that… read more here.
Keywords: pbp4; resistance; bpr; activity ... See more keywords
Recognition of Peptidoglycan Fragments by the Transpeptidase PBP4 From Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.03223
Abstract: Peptidoglycan (PG) is an essential component of the cell envelope, maintaining bacterial cell shape and protecting it from bursting due to turgor pressure. The monoderm bacterium Staphylococcus aureus has a highly cross-linked PG, with ~90%… read more here.
Keywords: staphylococcus aureus; activity; peptide stems; pbp4 ... See more keywords
Identification of Staphylococcus aureus Penicillin Binding Protein 4 (PBP4) Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11101351
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is a global healthcare concern. Such resistance has historically been attributed to the acquisition of mecA (or mecC), which encodes an alternative penicillin binding protein, PBP2a, with low β-lactam affinity. However,… read more here.
Keywords: binding protein; pbp4 inhibitors; pbp4; penicillin binding ... See more keywords