Application of Physiologically Based Pharmacokinetic Modeling to Inform Dose Selection of Mezigdomide in a Phase I Drug-Drug Interaction Study.
Sign Up to like & getrecommendations! Published in 2025 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.70082
Abstract: Mezigdomide (MEZI) is an oral, highly potent CELMoD™ agent with promising antitumor and immune-stimulatory activity, optimized for Aiolos and Ikaros degradation. Preclinical evidence suggests MEZI is primarily metabolized by cytochrome P450 (CYP) 3A4/5 and has… read more here.
Keywords: pbpk; based pharmacokinetic; drug drug; drug ... See more keywords
Use of normalized prediction distribution errors for assessing population physiologically-based pharmacokinetic model adequacy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-020-09684-2
Abstract: Currently employed methods for qualifying population physiologically-based pharmacokinetic (Pop-PBPK) model predictions of continuous outcomes (e.g., concentration–time data) fail to account for within-subject correlations and the presence of residual error. In this study, we propose a… read more here.
Keywords: population physiologically; model; pop pbpk; pbpk ... See more keywords
IMI – oral biopharmaceutics tools project – evaluation of bottom‐up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2016.09.027
Abstract: &NA; Predicting oral bioavailability (Foral) is of importance for estimating systemic exposure of orally administered drugs. Physiologically‐based pharmacokinetic (PBPK) modelling and simulation have been applied extensively in biopharmaceutics recently. The Oral Biopharmaceutical Tools (OrBiTo) project… read more here.
Keywords: oral biopharmaceutics; pbpk; evaluation; database ... See more keywords
The Promises of Quantitative Proteomics in Precision Medicine.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2016.11.017
Abstract: Precision medicine approach has a potential to ensure optimum efficacy and safety of drugs at individual patient level. Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) models could play a significant role in precision medicine by predicting… read more here.
Keywords: medicine; precision medicine; variability; quantitative proteomics ... See more keywords
Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized Medicine.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.04.035
Abstract: Personalized medicine aims to determine the most adequate treatment and dose regimen to obtain the maximum efficacy and minimum side effect by taking into account patients' characteristics. For numerous reasons, one being ethical and methodological… read more here.
Keywords: medicine; pbpk modeling; pbpk; usefulness pbpk ... See more keywords
Integration of Toxicogenomics and Physiologically Based Pharmacokinetic Modeling in Human Health Risk Assessment of Perfluorooctane Sulfonate.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.1c06479
Abstract: Toxicogenomics and physiologically based pharmacokinetic (PBPK) models are useful approaches in chemical risk assessment, but the methodology to incorporate toxicogenomic data into a PBPK model to inform risk assessment remains to be developed. This study… read more here.
Keywords: toxicogenomics physiologically; risk; physiologically based; pbpk ... See more keywords
Evaluation of the Success of High-Throughput Physiologically Based Pharmacokinetic (HT-PBPK) Modeling Predictions to Inform Early Drug Discovery
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00040
Abstract: Minimizing in vitro and in vivo testing in early drug discovery with the use of physiologically based pharmacokinetic (PBPK) modeling and machine learning (ML) approaches has the potential to reduce discovery cycle times and animal… read more here.
Keywords: drug discovery; pbpk modeling; pbpk; approach ... See more keywords
A comprehensive physiologically based pharmacokinetic (PBPK) model for nicotine in humans from using nicotine-containing products with different routes of exposure
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-05108-y
Abstract: Physiologically based pharmacokinetic (PBPK) modeling can be a useful tool for characterizing nicotine pharmacokinetics (PK) from use of tobacco products. We expand a previously published PBPK model to simulate a nicotine PK profile, following single… read more here.
Keywords: pharmacokinetic pbpk; pbpk model; based pharmacokinetic; model ... See more keywords
Retrospective use of PBPK modelling to understand a clinical drug–drug interaction between dextromethorphan and GSK1034702
Sign Up to like & getrecommendations! Published in 2017 at "Xenobiotica"
DOI: 10.1080/00498254.2016.1216630
Abstract: Abstract 1. In a clinical trial, a strong drug–drug interaction (DDI) was observed between dextromethorphan (DM, the object or victim drug) and GSK1034702 (the precipitant or perpetrator drug), following single and repeat doses. This study determined… read more here.
Keywords: drug interaction; drug; pbpk; gsk1034702 ... See more keywords
Efficient drug development of oseltamivir capsules based on process control, bioequivalence and PBPK modeling
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2022.2102647
Abstract: Abstract Oseltamivir phosphate is used to treat influenza. For registration of a generic product, bioequivalence studies are crucial, however, in vitro studies can sometimes replace the conventional human pharmacokinetic. To assess whether the dissolution profile… read more here.
Keywords: oseltamivir; bioequivalence; pbpk; drug development ... See more keywords
Extrapolation of lung pharmacokinetics of antitubercular drugs from preclinical species to humans using PBPK modelling
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkae109
Abstract: Abstract Objectives To develop physiologically based pharmacokinetic (PBPK) models for widely used anti-TB drugs, namely rifampicin, pyrazinamide, isoniazid, ethambutol and moxifloxacin lung pharmacokinetics (PK)—regarding both healthy and TB-infected tissue (cellular lesion and caseum)—in preclinical species… read more here.
Keywords: pbpk; lung; lung pharmacokinetics; preclinical species ... See more keywords