Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1693
Abstract: Physiologically‐based pharmacokinetic (PBPK) modeling has been extensively used to quantitatively translate in vitro data and evaluate temporal effects from drug–drug interactions (DDIs), arising due to reversible enzyme and transporter inhibition, irreversible time‐dependent inhibition, enzyme induction,… read more here.
Keywords: based pharmacokinetic; pbpk modeling; physiologically based; drug ... See more keywords
PBPK Modeling to Simulate the Fate of Compounds in Living Organisms.
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DOI: 10.1007/978-1-0716-1960-5_2
Abstract: Pharmacokinetics study the fate of xenobiotics in a living organism. Physiologically based pharmacokinetic (PBPK) models provide realistic descriptions of xenobiotics' absorption, distribution, metabolism, and excretion processes. They model the body as a set of homogeneous… read more here.
Keywords: simulate fate; compounds living; modeling simulate; pbpk modeling ... See more keywords
Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized Medicine.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.04.035
Abstract: Personalized medicine aims to determine the most adequate treatment and dose regimen to obtain the maximum efficacy and minimum side effect by taking into account patients' characteristics. For numerous reasons, one being ethical and methodological… read more here.
Keywords: medicine; pbpk modeling; pbpk; usefulness pbpk ... See more keywords
Physiologically Based Pharmacokinetic Modeling of Nanoparticles.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.10.037
Abstract: Nanoparticles are frequently designed to improve the pharmacokinetics profiles and tissue distribution of small molecules to prolong their systemic circulation, target specific tissue, or widen the therapeutic window. The multifunctionality of nanoparticles is frequently presented… read more here.
Keywords: pharmacokinetic modeling; disposition; based pharmacokinetic; pbpk modeling ... See more keywords
Evaluation of the Success of High-Throughput Physiologically Based Pharmacokinetic (HT-PBPK) Modeling Predictions to Inform Early Drug Discovery
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DOI: 10.1021/acs.molpharmaceut.2c00040
Abstract: Minimizing in vitro and in vivo testing in early drug discovery with the use of physiologically based pharmacokinetic (PBPK) modeling and machine learning (ML) approaches has the potential to reduce discovery cycle times and animal… read more here.
Keywords: drug discovery; pbpk modeling; pbpk; approach ... See more keywords
Physiologically-Based Pharmacokinetic Modeling of Tenofovir Disoproxil Fumarate in Pregnant Women.
Sign Up to like & getrecommendations! Published in 2023 at "Current drug metabolism"
DOI: 10.2174/1389200224666230130093314
Abstract: PURPOSE Physiological changes during pregnancy can affect antiretroviral drug processes and further influence drug efficacy and safety. Physiologically-based pharmacokinetic (PBPK) modeling offers a unique modality to predict PK in pregnant women. The objective of this… read more here.
Keywords: pbpk modeling; tdf; pregnant women; modeling tenofovir ... See more keywords
PBPK Modeling on Organs-on-Chips: An Overview of Recent Advancements
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.900481
Abstract: Organ-on-a-chip (OoC) is a new and promising technology, which aims to improve the efficiency of drug development and realize personalized medicine by simulating in vivo environment in vitro. Physiologically based pharmacokinetic (PBPK) modeling is believed… read more here.
Keywords: pbpk modeling; drug development; medicine; organ chip ... See more keywords
PBPK-PD modeling for the preclinical development and clinical translation of tau antibodies for Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.867457
Abstract: Disrupted tau proteostasis and transneuronal spread is a pathological hallmark of Alzheimer’s disease. Neurodegenerative diseases remain an unmet medical need and novel disease modifying therapeutics are paramount. Our objective was to develop a mechanistic mathematical… read more here.
Keywords: tau; development clinical; disease; alzheimer disease ... See more keywords
Semi-PBPK Modeling and Simulation to Evaluate the Local and Systemic Pharmacokinetics of OC-01(Varenicline) Nasal Spray
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DOI: 10.3389/fphar.2022.910629
Abstract: This study aimed to build a nasal semi-physiologically based pharmacokinetic (PBPK) model to predict the intranasal pharmacokinetic (PK) of the OC-01(varenicline) nasal spray and accelerate the development of this drug. Based on the physiology of… read more here.
Keywords: varenicline nasal; pbpk modeling; semi pbpk; nasal spray ... See more keywords
PBPK modeling to evaluate maximum tolerated doses: A case study with 3-chloroallyl alcohol
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1088011
Abstract: Introduction: A physiologically based pharmacokinetic (PBPK) model for 3-chloroallyl alcohol (3-CAA) was developed and used to evaluate the design of assays for the in vivo genotoxicity of 3-CAA. Methods: Model development was supported by read… read more here.
Keywords: pbpk modeling; pbpk model; model; alcohol ... See more keywords
PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates
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DOI: 10.3390/pharmaceutics13091325
Abstract: Uridine 5′-diphospho-glucuronosyltransferases (UGTs) are expressed in the small intestines, but prediction of first-pass extraction from the related metabolism is not well studied. This work assesses physiologically based pharmacokinetic (PBPK) modeling as a tool for predicting… read more here.
Keywords: tool predicting; metabolism; pbpk modeling; uridine diphospho ... See more keywords