Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening.
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DOI: 10.1021/acs.jmedchem.2c00864
Abstract: PBRM1 is a subunit of the PBAF chromatin remodeling complex that uniquely contains six bromodomains. PBRM1 can operate as a tumor suppressor or tumor promoter. PBRM1 is a tumor promoter in prostate cancer, contributing to… read more here.
Keywords: pbrm1 bromodomain; cell active; selective cell; pbrm1 ... See more keywords