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Published in 2021 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-0628
Abstract: This study demonstrates that PARP and ATR inhibitors are synthetic lethal with the loss of PBRM1, a PBAF-specific subunit, thus providing the rationale for assessing these inhibitors in patients with PBRM1-defective cancer. Inactivation of Polybromo…
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Keywords:
pbrm1;
parp atr;
pbrm1 defective;
cancer ... See more keywords