The TALE never ends: a comprehensive overview of the role of PBX1, a TALE transcription factor, in human developmental defects.
Sign Up to like & getrecommendations! Published in 2022 at "Human mutation"
DOI: 10.1002/humu.24388
Abstract: PBX1 is a highly conserved atypical homeodomain transcription factor (TF) belonging to the TALE (Three Amino acid Loop Extension) family. Dimerized with other TALE proteins, it can interact with numerous partners and reach dozens of… read more here.
Keywords: tale never; role; factor; transcription factor ... See more keywords
PBX1: a key character of the hallmarks of cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular medicine"
DOI: 10.1007/s00109-021-02139-2
Abstract: Pre-B-cell leukemia homeobox transcription factor 1 (PBX1) was first identified as part of a fusion protein resulting from the chromosomal translocation t(1;19) in pre-B cell acute lymphoblastic leukemias. Since then, PBX1 has been associated with… read more here.
Keywords: transcription; pbx1; cancer pbx1; cancer ... See more keywords
rs6426881 in the 3'-UTR of PBX1 is involved in breast and gastric cancers via altering the binding potential of miR-522-3p.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06756-5
Abstract: BACKGROUND Breast and gastric cancers are the most important diseases that lead to cancer death and social healthcare challenge. Overexpression of PBX1, a proto-oncogene, is correlated with the progression and metastasis of various cancers. For the… read more here.
Keywords: breast gastric; gastric cancers; pbx1; cancer ... See more keywords
The PBX1 lupus susceptibility gene regulates CD44 expression
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2017.02.016
Abstract: &NA; PBX1‐d is novel splice isoform of pre‐B‐cell leukemia homeobox 1 (PBX1) that lacks its DNA‐binding and Hox‐binding domains, and functions as a dominant negative. We have shown that PBX1‐d expression in CD4+ T cells… read more here.
Keywords: pbx1; expression; isoform pbx1; expression pbx1 ... See more keywords
PBX1 Improves Cognition and Reduces Amyloid-β Pathology in APP/PS1 Mice by Transcriptionally Activating the CRTC2-CREB Pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Aging cell"
DOI: 10.1111/acel.70311
Abstract: Alzheimer's disease (AD) is characterized by progressive cognitive decline, amyloid β (Aβ) deposition, and synaptic dysfunction. However, the mechanisms underlying neurodegeneration remain poorly understood. In this study, we investigated the therapeutic potential of PBX1, a… read more here.
Keywords: crtc2 creb; pbx1; pathology; app ps1 ... See more keywords
Lupus susceptibility gene Pbx1 controls the development, stability, and function of regulatory T cells via Rtkn2 expression
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adi4310
Abstract: The maintenance of regulatory T (Treg) cells critically prevents autoimmunity. Pre–B cell leukemia transcription factor 1 (Pbx1) variants are associated with lupus susceptibility, particularly through the expression of a dominant negative isoform Pbx1-d in CD4+… read more here.
Keywords: stability; pbx1; treg cells; cell ... See more keywords
Determination of the Origin of the t(1;19) TCF3-PBX1 Fusion By Genomic Inverse PCR for Exploration of Ligated Breakpoints (GIPFEL)
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-110521
Abstract: Pediatric acute lymphoblastic leukemia (ALL) is characterized by recurrent chromosomal translocations. The translocation t(1;19) that fuses the gene encoding the basic helix-loop-helix transcription factor TCF3 with the gene encoding the homeodomain protein PBX1 is the… read more here.
Keywords: fusion; pbx1; pcr; translocation ... See more keywords
PBX1 Co-Operates with FOXM1 to Regulate Myeloma Cell Proliferation and to Define an Ultra High-Risk chr1q Gain Myeloma Patient Subgroup
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-124109
Abstract: BACKGROUND: The biological basis for the adverse prognosis of chr1q gain/amplification (1q+) present in ~30% of patients with multiple myeloma (MM) remains ill-defined. The transcription factor (TF) Pre-B-cell leukaemia homeobox 1 (PBX1), encoded on chr1q,… read more here.
Keywords: pbx1; myeloma cell; foxm1; analysis ... See more keywords
PBX1 Participates in Estrogen-Mediated Bladder Cancer Progression and Chemo-Resistance Affecting Estrogen Receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Current cancer drug targets"
DOI: 10.2174/1568009622666220413084456
Abstract: BACKGROUND Bladder cancer (BCa) is a common cancer associated with high morbidity and mortality worldwide. Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to be involved in tumor progression. OBJECTIVE The aim of the… read more here.
Keywords: estrogen receptors; bca; progression; pbx1 ... See more keywords
Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842
Sign Up to like & getrecommendations! Published in 2024 at "Haematologica"
DOI: 10.3324/haematol.2023.283647
Abstract: t(1;19)(q23;p13) is one of the most common translocation genes in childhood acute lymphoblastic leukemia (ALL) and is also present in acute myeloid leukemia (AML) and mixed-phenotype acute leukemia (MPAL). This translocation results in the formation… read more here.
Keywords: pbx1; leukemia; e2a pbx1; he2a pbx1 ... See more keywords
Functional Characterization of a Novel PBX1 De Novo Missense Variant Identified in a Pediatric Patient with CAKUT
Sign Up to like & getrecommendations! Published in 2025 at "Genes"
DOI: 10.3390/genes16111346
Abstract: Background: Genetic variants in Pre-B cell Leukemia Factor 1 (PBX1) transcription factor (TF) have been associated with Congenital Anomalies of the Kidney and Urinary Tract (CAKUT). This study aims to functionally characterize a novel missense… read more here.
Keywords: cakut; missense variant; pbx1; patient ... See more keywords