The TALE never ends: a comprehensive overview of the role of PBX1, a TALE transcription factor, in human developmental defects.
Sign Up to like & getrecommendations! Published in 2022 at "Human mutation"
DOI: 10.1002/humu.24388
Abstract: PBX1 is a highly conserved atypical homeodomain transcription factor (TF) belonging to the TALE (Three Amino acid Loop Extension) family. Dimerized with other TALE proteins, it can interact with numerous partners and reach dozens of… read more here.
Keywords: tale never; role; factor; transcription factor ... See more keywords
PBX1: a key character of the hallmarks of cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular medicine"
DOI: 10.1007/s00109-021-02139-2
Abstract: Pre-B-cell leukemia homeobox transcription factor 1 (PBX1) was first identified as part of a fusion protein resulting from the chromosomal translocation t(1;19) in pre-B cell acute lymphoblastic leukemias. Since then, PBX1 has been associated with… read more here.
Keywords: transcription; pbx1; cancer pbx1; cancer ... See more keywords
rs6426881 in the 3'-UTR of PBX1 is involved in breast and gastric cancers via altering the binding potential of miR-522-3p.
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DOI: 10.1007/s11033-021-06756-5
Abstract: BACKGROUND Breast and gastric cancers are the most important diseases that lead to cancer death and social healthcare challenge. Overexpression of PBX1, a proto-oncogene, is correlated with the progression and metastasis of various cancers. For the… read more here.
Keywords: breast gastric; gastric cancers; pbx1; cancer ... See more keywords
The PBX1 lupus susceptibility gene regulates CD44 expression
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2017.02.016
Abstract: &NA; PBX1‐d is novel splice isoform of pre‐B‐cell leukemia homeobox 1 (PBX1) that lacks its DNA‐binding and Hox‐binding domains, and functions as a dominant negative. We have shown that PBX1‐d expression in CD4+ T cells… read more here.
Keywords: pbx1; expression; isoform pbx1; expression pbx1 ... See more keywords
Determination of the Origin of the t(1;19) TCF3-PBX1 Fusion By Genomic Inverse PCR for Exploration of Ligated Breakpoints (GIPFEL)
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DOI: 10.1182/blood-2018-99-110521
Abstract: Pediatric acute lymphoblastic leukemia (ALL) is characterized by recurrent chromosomal translocations. The translocation t(1;19) that fuses the gene encoding the basic helix-loop-helix transcription factor TCF3 with the gene encoding the homeodomain protein PBX1 is the… read more here.
Keywords: fusion; pbx1; pcr; translocation ... See more keywords
PBX1 Co-Operates with FOXM1 to Regulate Myeloma Cell Proliferation and to Define an Ultra High-Risk chr1q Gain Myeloma Patient Subgroup
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DOI: 10.1182/blood-2019-124109
Abstract: BACKGROUND: The biological basis for the adverse prognosis of chr1q gain/amplification (1q+) present in ~30% of patients with multiple myeloma (MM) remains ill-defined. The transcription factor (TF) Pre-B-cell leukaemia homeobox 1 (PBX1), encoded on chr1q,… read more here.
Keywords: pbx1; myeloma cell; foxm1; analysis ... See more keywords
PBX1 Participates in Estrogen-Mediated Bladder Cancer Progression and Chemo-Resistance Affecting Estrogen Receptors.
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DOI: 10.2174/1568009622666220413084456
Abstract: BACKGROUND Bladder cancer (BCa) is a common cancer associated with high morbidity and mortality worldwide. Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to be involved in tumor progression. OBJECTIVE The aim of the… read more here.
Keywords: estrogen receptors; bca; progression; pbx1 ... See more keywords