Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
Sign Up to like & getrecommendations! Published in 2024 at "Febs Letters"
DOI: 10.1002/1873-3468.70059
Abstract: Autosomal-dominant polycystic kidney disease (ADPKD) is caused by mutations affecting polycystin-1 (PC1) or polycystin-2 (PC2). Recent structural data suggest that PC1 and PC2 can form heterotetrameric ion channels with a 3:1 stoichiometry, with the channel… read more here.
Keywords: function; polycystin; ion; pc2 pc1 ... See more keywords
Changes in the Care Setting of First Consults to Palliative and Supportive Care Over a Seven-Year Period.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pain and symptom management"
DOI: 10.1016/j.jpainsymman.2018.10.269
Abstract: CONTEXT Optimal benefits from palliative care (PC) are achieved when first consults (PC1) occur early, in the outpatient setting. Late PC1, like those in the intensive care unit (ICU), limit these benefits. OBJECTIVES The objective… read more here.
Keywords: pc1; first consults; cancer; care ... See more keywords
Isolated Proton Aurora Driven by EMIC Pc1 Wave: PWING, Swarm, and NOAA POES Multi‐Instrument Observations
Sign Up to like & getrecommendations! Published in 2021 at "Geophysical Research Letters"
DOI: 10.1029/2021gl095090
Abstract: We report the concurrent observations of F‐region plasma changes and field‐aligned currents (FACs) above isolated proton auroras (IPAs) associated with electromagnetic ion cyclotron Pc1 waves. Key events on March 19, 2020 and September 12, 2018… read more here.
Keywords: pc1 wave; isolated proton; proton; noaa poes ... See more keywords
Gαi-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21873-1
Abstract: Hypertension and aneurysm are frequently associated with autosomal dominant polycystic kidney disease (ADPKD) caused by polycystin-1 (PC1) mutations, which is closely related to endothelial dysfunction. PC1 is an atypical G-protein-coupled receptor that activates G-proteins by… read more here.
Keywords: pc1; endothelial function; trpc4 activation; mediated trpc4 ... See more keywords
Polycystin‐1 and hydrostatic pressure are implicated in glioblastoma pathogenesis in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17212
Abstract: The mechanobiological aspects of glioblastoma (GBM) pathogenesis are largely unknown. Polycystin‐1 (PC1) is a key mechanosensitive protein which perceives extracellular mechanical cues and transforms them into intracellular biochemical signals that elicit a change in cell… read more here.
Keywords: hydrostatic pressure; pc1; gbm; pathogenesis ... See more keywords
Polycystin‐1 regulates cell proliferation and migration through AKT/mTORC2 pathway in a human craniosynostosis cell model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17266
Abstract: Craniosynostosis is the premature fusion of skull sutures and has a severe pathological impact on childrens’ life. Mechanical forces are capable of triggering biological responses in bone cells and regulate osteoblastogenesis in cranial sutures, leading… read more here.
Keywords: proliferation migration; craniosynostosis; akt; pc1 ... See more keywords
Abstract 4369552: Role of the Polycystin-1 C-Terminus in Regulating Cardiomyocyte Protein Synthesis
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4369552
Abstract: Introduction: Polycystin-1 (PC1) is a large transmembrane protein expressed across the body. While PC1 mutations are responsible for ~85% of autosomal dominant polycystic kidney disease (ADPKD) cases, PC1 is increasingly recognized as a key regulator… read more here.
Keywords: ipsc cms; pc1; protein synthesis; role ... See more keywords
A cross-sectional study of the role of epithelial cell injury in kidney transplant outcomes
Sign Up to like & getrecommendations! Published in 2025 at "JCI Insight"
DOI: 10.1172/jci.insight.188658
Abstract: Background. Expression of acute kidney injury–associated (AKI-associated) transcripts in kidney transplants may reflect recent injury and accumulation of epithelial cells in “failed repair” states. We hypothesized that the phenomenon of failed repair could be associated… read more here.
Keywords: pc1; kidney transplant; failed repair; injury ... See more keywords
A statistical analysis of Pc1–2 waves at a near-cusp station in Antarctica
Sign Up to like & getrecommendations! Published in 2017 at "Earth, Planets and Space"
DOI: 10.1186/s40623-017-0738-8
Abstract: A statistical study of Pc1–2 waves at southern polar latitudes is presented. Ultra-low frequency geomagnetic field measurements collected at the Italian station Mario Zucchelli (Terra Nova Bay, Antarctica, altitude-adjusted corrected geomagnetic latitude 80°S, MLT = UT − 8) from… read more here.
Keywords: station; pc1; statistical analysis; solar cycle ... See more keywords
Changes in the setting of first consults to palliative and supportive care over a 7-year period.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.34_suppl.86
Abstract: 86 Background: Optimal benefits from palliative cancer care (PC) are achieved when first consults (PC1) occur early, ideally in the outpatient setting. Late PC1, such as those occurring in the intensive care unit (ICU), limit… read more here.
Keywords: pc1; proportion pc1; icu; first consults ... See more keywords
Polycystin-1 Is a Crucial Regulator of BIN1 Expression and T-Tubule Remodeling Associated with the Development of Dilated Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010667
Abstract: Cardiomyopathy is commonly observed in patients with autosomal dominant polycystic kidney disease (ADPKD), even when they have normal renal function and arterial pressure. The role of cardiomyocyte polycystin-1 (PC1) in cardiovascular pathophysiology remains unknown. PC1… read more here.
Keywords: tubule remodeling; pc1; bin1; expression ... See more keywords