Salidroside protected against MPP+‐induced Parkinson's disease in PC12 cells by inhibiting inflammation, oxidative stress and cell apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1719
Abstract: The present study aimed to investigate the protective effects of salidroside (SAL) on 1‐methyl‐4‐phenylpyridinium (MPP+)‐induced PC12 cell model for Parkinson's disease. PC12 cells were pretreated with SAL in different concentrations and then exposed to MPP+.… read more here.
Keywords: mpp induced; pc12 cells; apoptosis; parkinson disease ... See more keywords
The neuroprotective effects of alpha‐lipoic acid on an experimental model of Alzheimer's disease in PC12 cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4213
Abstract: With the growth of the aging population, the prevalence of Alzheimer's disease (AD) has increased and influenced the work and daily life of AD patients, imposing a heavy burden on society and the patients' families.… read more here.
Keywords: pc12 cells; lipoic acid; alpha lipoic; disease ... See more keywords
N6-(2-hydroxyethyl)-adenosine from Cordyceps cicadae attenuates hydrogen peroxide induced oxidative toxicity in PC12 cells
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-019-00440-1
Abstract: N6-(2-hydroxyethyl)-adenosine (HEA), is one of the active molecule found in Cordyceps cicadae. The protective effect of HEA against H2O2 induced oxidative damage in PC12 cells and the mechanism of action was investigated. The cells were… read more here.
Keywords: pc12 cells; induced oxidative; toxicity; hydroxyethyl adenosine ... See more keywords
IL-5 blocks apoptosis and tau hyperphosphorylation induced by Aβ25–35 peptide in PC12 cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-017-0550-8
Abstract: The primary features of Alzheimer’s disease (AD) are extracellular amyloid plaques consisting mainly of deposits of amyloid β (Aβ) peptides and intracellular neurofibrillary tangles (NFTs). Sets of evidence suggest that interleukin-5 (IL-5) is involved in… read more here.
Keywords: apoptosis tau; pc12 cells; blocks apoptosis; hyperphosphorylation ... See more keywords
Activation of NPY-Y2 receptors ameliorates disease pathology in the R6/2 mouse and PC12 cell models of Huntington's disease
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.01.001
Abstract: ABSTRACT Huntington's disease (HD) is a monogenic inherited polyglutamine‐mediated neurodegenerative disorder for which effective therapies are currently unavailable. Neuropeptide Y (NPY) has been implicated as a potential therapeutic target in several neurodegenerative diseases, including HD.… read more here.
Keywords: intranasal npy; npy npy13; pathology; activation ... See more keywords
Dehydropachymic acid decreases bafilomycin A1 induced β-Amyloid accumulation in PC12 cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.01.007
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Fuling, the sclerotium of Poria cocos, was frequently used in traditional Chinese medicine (TCM) formulae for Alzheimer's disease (AD) intervention over the past 10 centuries. And its extracts exhibited significant effects in both… read more here.
Keywords: accumulation; pc12 cells; app; pc12 ... See more keywords
Egg yolk phosphatidylcholine: Extraction, purification and its potential neuroprotective effect on PC12 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.03.037
Abstract: Abstract Phosphatidylcholine (PC), a main phospholipid component in egg yolk, provides nourishment and protection for the body. In this study, an attempt has been made to explore the neuroprotective effect of PC that extracted and… read more here.
Keywords: egg; egg yolk; neuroprotective effect; pc12 ... See more keywords
3β,23,28-Trihydroxy-12-oleanene 3β-Caffeate from Desmodium sambuense-Induced Neurogenesis in PC12 Cells Mediated by ER Stress and BDNF-TrkB Signaling Pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00939
Abstract: 3β,23,28-Trihydroxy-12-oleanene 3β-caffeate (compound 1) is a neuritogenic pentacyclic triterpenoid, which was isolated from Desmodium sambuense based on a PC12 cell bioassay system. Compound 1 induced neurite outgrowth dose-dependently in PC12 cells and primary cortical neurons… read more here.
Keywords: pc12 cells; oleanene caffeate; compound; pc12 ... See more keywords
SET domain containing 7 promotes oxygen-glucose deprivation/reoxygenation-induced PC12 cell inflammation and oxidative stress by regulating Keap1/Nrf2/ARE and NF-κB pathways
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2045830
Abstract: ABSTRACT Oxidative stress and inflammation are implicated in the pathogenesis of cerebral ischemia-reperfusion (I/R) injury. SETD7 (SET Domain Containing 7) functions as a histone lysine methyltransferase, participates in cardiac lineage commitment, and silence of SETD7… read more here.
Keywords: cell; inflammation; pc12; oxidative stress ... See more keywords
The cytological and electrophysiological effects of silver nanoparticles on neuron-like PC12 cells
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0277942
Abstract: The aim of this study was to investigate the toxic effects and mechanism of silver nanoparticles (SNPs) on the cytological and electrophysiological properties of rat adrenal pheochromocytoma (PC12) cells. Different concentrations of SNPs (20 nm)… read more here.
Keywords: electrical excitability; silver nanoparticles; pc12; atp content ... See more keywords
Superparamagnetic iron oxide nanoparticles combined with NGF and quercetin promote neuronal branching morphogenesis of PC12 cells
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s191878
Abstract: Background The investigation of agents promoting recovery of nerve regeneration following neurodegenerative diseases has been the most important issue in neuroscience. Nerve growth factor (NGF) and quercetin as potential flavonoids could possibly have therapeutic applications… read more here.
Keywords: iron oxide; pc12; ngf quercetin; oxide nanoparticles ... See more keywords