Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
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DOI: 10.1002/1873-3468.70059
Abstract: Autosomal-dominant polycystic kidney disease (ADPKD) is caused by mutations affecting polycystin-1 (PC1) or polycystin-2 (PC2). Recent structural data suggest that PC1 and PC2 can form heterotetrameric ion channels with a 3:1 stoichiometry, with the channel… read more here.
Keywords: function; polycystin; ion; pc2 pc1 ... See more keywords