Assessing data accuracy in a large multi-institutional quality improvement registry: an update from the Pediatric Cardiac Critical Care Consortium (PC4).
Sign Up to like & getrecommendations! Published in 2021 at "Cardiology in the young"
DOI: 10.1017/s1047951121004984
Abstract: BACKGROUND The Pediatric Cardiac Critical Care Consortium (PC4) is a multi-institutional quality improvement registry focused on the care delivered in the cardiac ICU for patients with CHD and acquired heart disease. To assess data quality,… read more here.
Keywords: cardiac critical; care; critical care; consortium ... See more keywords
Phosphorylation-dependent association of human chromatin protein PC4 to linker histone H1 regulates genome organization and transcription
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac450
Abstract: Abstract Human Positive Coactivator 4 (PC4) is a multifaceted chromatin protein involved in diverse cellular processes including genome organization, transcription regulation, replication, DNA repair and autophagy. PC4 exists as a phospho-protein in cells which impinges… read more here.
Keywords: histone; transcription; pc4; linker histone ... See more keywords
Positive Cofactor 4 as a Potential Radiation Biodosimeter for Early Assessment
Sign Up to like & getrecommendations! Published in 2022 at "Dose-Response"
DOI: 10.1177/15593258221081317
Abstract: During a major radiation event, a large number of people need to be rapidly assessed for radiation damage to ensure effective medical treatment and efficient use of medical resources. However, current techniques cannot meet the… read more here.
Keywords: early assessment; positive cofactor; pc4; radiation ... See more keywords
Positive cofactor 4 (PC4) contributes to the regulation of replication-dependent canonical histone gene expression
Sign Up to like & getrecommendations! Published in 2018 at "BMC Molecular Biology"
DOI: 10.1186/s12867-018-0110-y
Abstract: BackgroundCore canonical histones are required in the S phase of the cell cycle to pack newly synthetized DNA, therefore the expression of their genes is highly activated during DNA replication. In mammalian cells, this increment… read more here.
Keywords: expression; histone; pc4; gene ... See more keywords
Down regulation of human positive coactivator 4 suppress tumorigenesis and lung metastasis of osteosarcoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18290
Abstract: Osteosarcoma is a kind of primary malignant bone tumor with the highest incidence and an extraordinarily poor prognosis and early pulmonary metastasis formation as a frequent occurrence. Transcriptional positive coactivator 4 (PC4) has multiple functions… read more here.
Keywords: osteosarcoma; metastasis; pc4; positive coactivator ... See more keywords
The Catalytic Subunit of Schizosaccharomyces pombe CK2 (Cka1) Negatively Regulates RNA Polymerase II Transcription through Phosphorylation of Positive Cofactor 4 (PC4)
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169499
Abstract: Positive cofactor 4 (PC4) is a transcriptional coactivator that plays important roles in transcription and DNA replication. In mammals, PC4 is phosphorylated by CK2, and this event downregulates its RNA polymerase II (RNAPII) coactivator function.… read more here.
Keywords: transcription; cka1; pc4; fission yeast ... See more keywords