Striking the Right Balance With Prostate Cancer Screening.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2022.2174
Abstract: Desai and colleagues,1 analyzing Surveillance, Epidemiology, and End Results data from 2004 through 2018, found significantly increasing incidence rates of metastatic prostate cancer (mPCa) among men aged 45 to 74 years (during the period 2010-2018)… read more here.
Keywords: recommendation; incidence; prostate; pca ... See more keywords
Transcriptional downregulation of miR‐127‐3p by CTCF promotes prostate cancer bone metastasis by targeting PSMB5
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13624
Abstract: Prostate cancer (PCa) is one of the most common cancers in males and particularly tends to metastasize to bone. Currently, metastatic bone disease is incurable, and new therapies need to be developed. Our study aims… read more here.
Keywords: ctcf; bone; pca; bone metastasis ... See more keywords
Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13441
Abstract: The androgen receptor (AR) is an established orchestrator of cell metabolism in prostate cancer (PCa), notably by inducing an oxidative mitochondrial program. Intriguingly, AR regulates cytoplasmic isocitrate dehydrogenase 1 (IDH1) but not its mitochondrial counterparts… read more here.
Keywords: cycle; prostate cancer; idh1; isocitrate dehydrogenase ... See more keywords
Acetylated KHSRP impairs DNA‐damage‐response‐related mRNA decay and facilitates prostate cancer tumorigenesis
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13634
Abstract: Androgen‐regulated DNA damage response (DDR) is one of the essential mechanisms in prostate cancer (PCa), a hormone‐sensitive disease. The heterogeneous nuclear ribonucleoprotein K (hnRNPK)‐homology splicing regulatory protein known as far upstream element‐binding protein 2 (KHSRP)… read more here.
Keywords: dna damage; damage response; prostate cancer; pca ... See more keywords
IL-1β Is an Androgen-Responsive Target in Macrophages for Immunotherapy of Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202206889
Abstract: Great attention is paid to the role of androgen receptor (AR) as a central transcriptional factor in driving the growth of prostate cancer (PCa) epithelial cells. However, the understanding of the role of androgen in… read more here.
Keywords: androgen responsive; prostate cancer; pca; androgen ... See more keywords
Proteomic Identification of Small Extracellular Vesicle Proteins LAMB1 and Histone H4 for Prostate Cancer Diagnosis and Risk Stratification
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202402509
Abstract: Diagnosis and stratification of prostate cancer (PCa) patients using the prostate‐specific antigen (PSA) test is challenging. Extracellular vesicles (EVs), as a new star of liquid biopsy, has attracted interest to complement inaccurate PSA screening and… read more here.
Keywords: diagnosis; cancer; stratification; risk ... See more keywords
PTBP1 Regulates DNMT3B Alternative Splicing by Interacting With RALY to Enhance the Radioresistance of Prostate Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202405997
Abstract: Radiotherapy is a curative arsenal for prostate cancer (PCa), but radioresistance seriously compromises its effectiveness. Dysregulated RNA splicing factors are extensively involved in tumor progression. Nonetheless, the role of splicing factors in radioresistance remains largely… read more here.
Keywords: splicing factors; dnmt3b; prostate cancer; pca ... See more keywords
Targeting Splenic Myeloid Cells with Nanobiologics to Prevent Postablative Pancreatic Cancer Recurrence via Inducing Antitumor Peripheral Trained Immunity
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202413562
Abstract: Minimally invasive irreversible electroporation ablation shows promise for pancreatic cancer (PCa), but the high recurrence and metastasis rates pose a therapeutic challenge for loco‐regional ablation treatment. Immunotherapy holds promise for preventing tumor recurrence, however, its… read more here.
Keywords: myeloid cells; pca; splenic myeloid; trained immunity ... See more keywords
Role of eIF4E on epithelial‐mesenchymal transition, invasion, and chemoresistance of prostate cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Communications"
DOI: 10.1002/cac2.12011
Abstract: Dear Editor, Prostate cancer (PCa) is the most common cancer and second leading cause of cancer death for men in the United States [1]. PCa with similar Gleason score has been reported to show substantial… read more here.
Keywords: chemoresistance; prostate cancer; pca; role eif4e ... See more keywords
Deciphering the scalene association among type‐2 diabetes mellitus, prostate cancer, and chronic myeloid leukemia via enrichment analysis of disease‐gene network
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.1845
Abstract: The potential biological relationship between type‐2 diabetes mellitus (T2DM) has been focused in numerous studies. To investigate the molecular associations among T2DM, prostate cancer (PCa), and chronic myeloid leukemia (CML), using a biomolecular network enrichment… read more here.
Keywords: enrichment analysis; cml pca; overlapping genes; pca ... See more keywords
Different predictive values of microvessel density for biochemical recurrence among different PCa populations: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5093
Abstract: Several studies have explored the relationship between intratumoral microvessel density (MVD) and the risk of postoperative biochemical recurrence (BCR) in prostate cancer (PCa), although the results are contradictory. Therefore, we conducted a meta‐analysis to investigate… read more here.
Keywords: biochemical recurrence; microvessel density; meta analysis; pca ... See more keywords