USP33 enhances cell survival and stemness by deubiquitinating CTNNB1 in BXPC-3 and SW1990 cells.
Sign Up to like & getrecommendations! Published in 2023 at "Cell biology international"
DOI: 10.1002/cbin.12024
Abstract: Ubiquitin-specific protease 33 (USP33) has been implicated in various cancers, but its biological function and mechanism of action remain unknown in pancreatic cancer (PCa) as a deubiquitinating enzyme. Herein, we report that USP33 silencing inhibits… read more here.
Keywords: cell; bxpc; pca; sw1990 ... See more keywords
Delineating role of NF‐κB and interacting cytokines during prostate cancer‐induced osteoclastogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29856
Abstract: Prostate cancer (PCa) frequently metastasizes to the bone leading to devastating complications such as severe pain and fracture. However, the mechanisms by which PCa cells cause bone loss remain less understood. We investigated the role… read more here.
Keywords: induced osteoclastogenesis; prostate cancer; role; pca cells ... See more keywords
Downregulation of TRPM7 suppressed migration and invasion by regulating epithelial–mesenchymal transition in prostate cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Medical Oncology"
DOI: 10.1007/s12032-017-0987-1
Abstract: Metastasis is a leading cause of death in patients with prostate cancer (PCa). Transient receptor potential channel 7 (TRPM7) functions as a Mg2+/Ca2+-permeable channel as well as a protein kinase that regulate various cellular processes… read more here.
Keywords: pca; trpm7; migration invasion; pca cells ... See more keywords
Blocking secretion of exosomes by GW4869 dampens CD8+ T cell exhaustion and prostate cancer progression
Sign Up to like & getrecommendations! Published in 2025 at "Human Cell"
DOI: 10.1007/s13577-025-01257-0
Abstract: Functional exhaustion of T lymphocytes is considered an important factor in the failure of tumor treatment. Accumulating evidence has shown that tumor cells cultivate their immune microenvironment through secreting exosomes. However, the mechanism through which… read more here.
Keywords: pca cells; prostate cancer; exhaustion; cell ... See more keywords
Osteoblast-secreted WISP-1 promotes adherence of prostate cancer cells to bone via the VCAM-1/integrin α4β1 system.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.03.050
Abstract: Bone metastasis is a frequent occurrence in prostate cancer (PCa) that is associated with severe complications such as fracture, bone pain and hypercalcemia. The cross-talk between metastatic cancer cells and bone is critical to the… read more here.
Keywords: pca cells; bone; cancer cells; cancer ... See more keywords
Proteomic Analysis of Microsomal Proteins Reveals That MVP Is Crucial for the Secretion of GDF-15, Which in Turn Promotes the Neuroendocrine Differentiation of PCa Cells.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.4c00694
Abstract: Neuroendocrine prostate cancer (NEPC) is an aggressive androgen-independent PCa (AIPC) that tends to resist treatment. Understanding its progression and resistance could improve survival outcomes. Previous studies on PCa cells highlighted microsomal proteins' role in PCa… read more here.
Keywords: microsomal proteins; lncap; pca cells; analysis ... See more keywords
Exosomal lncAY927529 enhances prostate cancer cell proliferation and invasion through regulating bone microenvironment.
Sign Up to like & getrecommendations! Published in 2021 at "Cell cycle"
DOI: 10.1080/15384101.2021.1992853
Abstract: Exosomes mediate the interaction between cancer cells and their microenvironment, and play a key role in tumor development. Although exosomes can package lncRNAs to mediate extracellular communication, the role of exosomal lncRNA AY927529 in prostate… read more here.
Keywords: lncay927529; proliferation invasion; exosomes derived; pca cells ... See more keywords
STAT3 as a target for sensitizing prostate cancer cells to irradiation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrab117
Abstract: Abstract Radioresistance of prostate cancer (PCa) is a major factor leading to local failure of radiotherapy. STAT3 is an oncogenic protein that was recently found to be activated in PCa tumors. This study aimed to… read more here.
Keywords: stat3 blockade; pca; radiation; stat3 ... See more keywords
Abstract 2026: Loss of fibroblasts-dependent androgen receptor activation in prostate cancer cells develops castration-resistant prostate cancer
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-2026
Abstract: Well-differentiated prostate cancer (PCa) cells are generally androgen/androgen receptor (AR)-dependent, i.e. AR signaling regulates cell cycle and differentiation. Loss of AR signaling after androgen deprivation therapy (ADT) triggers AR-independent outgrowth, generating poorly differentiated uncontrollable PCa… read more here.
Keywords: cancer; prostate cancer; pca cells; castration ... See more keywords
Abstract 3983: Direct contact of heterogeneous fibroblasts with cancer cells regulates the invasive phenotype of prostate cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-3983
Abstract: In the tumor microenvironment of prostate cancer (PCa), cancer cells frequently invade the surrounding stroma in the way of single cell migration (SCM) or collective cell migration (CCM). This phenomenon can be responsible for the… read more here.
Keywords: lncap cells; pca cells; pcprf; cancer cells ... See more keywords
Abstract 3647: Anti-tumor actions of neutrophils are mediated via STAT5 inhibition
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3647
Abstract: The overall patient survival rate drops dramatically when localized prostate cancer (PCa) progresses to bone metastatic prostate cancer (BM-PCa). The treatment for BM-PCa is limited to palliative therapy, and it is currently incurable. Neutrophils are… read more here.
Keywords: via stat5; bone; stat5; pca ... See more keywords