PCAF regulates cardiac muscle function via non-epigenetic regulation of ACTA1 acetylation
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734987
Abstract: Historically, lysine acetylation has been studied in the epigenetic regulation of gene expression, in which it is known to play key roles in cardiac remodeling and dysfunction. However, recent evidence suggests that non-histone protein acetylation… read more here.
Keywords: acetylation; pcaf; acta1; physiology ... See more keywords
PCAF Accelerates Vascular Senescence via the Hippo Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/1200602
Abstract: P300/CBP-Associated Factor (PCAF), one of the histone acetyltransferases (HATs), is known to be involved in cell growth and/or differentiation. PCAF is reported to be involved in atherosclerotic plaques and neointimal formation. However, its role in… read more here.
Keywords: vascular senescence; signaling pathway; pcaf; senescence ... See more keywords
PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells
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DOI: 10.1186/s12885-017-3959-0
Abstract: BackgroundLin28B and its paralog Lin28A are small RNA binding proteins that have similar inhibitory effects, although they target separate steps in the maturation of let-7 miRNAs in mammalian cells. Because Lin28B participates in the promotion… read more here.
Keywords: h1299 cells; lung adenocarcinoma; pcaf; h1299 ... See more keywords
PCAF‐mediated acetylation of ISX recruits BRD4 to promote epithelial‐mesenchymal transition
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DOI: 10.15252/embr.201948795
Abstract: Epigenetic regulation is important for cancer progression; however, the underlying mechanisms, particularly those involving protein acetylation, remain to be fully understood. Here, we show that p300/CBP‐associated factor (PCAF)‐dependent acetylation of the transcription factor intestine‐specific homeobox… read more here.
Keywords: isx; acetylation isx; mesenchymal transition; pcaf ... See more keywords
Downregulation of P300/CBP-Associated Factor Protects from Vascular Aging via Nrf2 Signal Pathway Activation
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DOI: 10.3390/ijms232012574
Abstract: Increasing evidence has shown that vascular aging has a key role in the pathogenesis of vascular diseases. P300/CBP-associated factor (PCAF) is involved in many vascular pathological processes, but the role of PCAF in vascular aging… read more here.
Keywords: pcaf; p300 cbp; factor; downregulation ... See more keywords
Metformin Induces Apoptosis in Human Pancreatic Cancer (PC) Cells Accompanied by Changes in the Levels of Histone Acetyltransferases (Particularly, p300/CBP-Associated Factor (PCAF) Protein Levels)
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16010115
Abstract: Accumulating evidence (mainly from experimental research) suggests that metformin possesses anticancer properties through the induction of apoptosis and inhibition of the growth and proliferation of cancer cells. However, its effect on the enzymes responsible for… read more here.
Keywords: pcaf; p300 cbp; cbp; metformin ... See more keywords