PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23533
Abstract: Although Poly C Binding Protein 1 (PCBP1) affects cellular ferroptosis and mitochondrial dysfunction, the mechanisms by which PCBP1 regulates bladder cancer (BC) cell functions are unknown. In this study, two BC cell lines (T24 and… read more here.
Keywords: mitochondria injury; injury ferroptosis; pcbp1; ferroptosis ... See more keywords
Borax regulates iron chaperone- and autophagy-mediated ferroptosis pathway in glioblastoma cells.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23797
Abstract: Glioblastoma (GBM) is classified as a stage-IV glioma. Unfortunately, there are currently no curative treatments for GBM. Poly(rC)-binding protein 1 (PCBP1) is a cytosolic iron chaperone with diverse functions. PCBP1 is also known to regulate… read more here.
Keywords: cell; pcbp1; iron chaperone; u87 cells ... See more keywords
Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20170114
Abstract: Thyroid cancer patients with high miR-490-3p inhibit translation of PCBP1 mRNA, whereas in patients with low miR-490-3p PCBP1 mRNA expression is high; however, the resultant protein is targeted for degradation through the proteasome. The objective… read more here.
Keywords: protein; thyroid cancer; expression; pcbp1 ... See more keywords
PolyC-RNA-binding protein 1 (PCBP1) enhances tropomyosin 3 (TPM3) mRNA stability to promote the progression of esophageal squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2053801
Abstract: The molecular etiology of esophageal squamous cell carcinoma (ESCC) has not been fully elucidated. Understanding of the molecular mechanisms and finding new therapeutic targets for ESCC is of crucial importance. PolyC-RNA-binding protein 1 (PCBP1) is… read more here.
Keywords: tpm3 mrna; pcbp1; mrna; protein ... See more keywords
Abstract 7460: Characterizing the role of PCBP1 in the activation of the cGAS-STING/type I Interferon axis to promote anti-tumor immunity
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-7460
Abstract: The emergence of immunotherapies has encouraged the need to better understand the molecular mechanisms that modulate the tumor immune microenvironment to kill cancer cells as well as the strategies used by cancer cells to evade… read more here.
Keywords: cancer; activation cgas; pcbp1; tumor ... See more keywords
Intracellular iron levels alter the protein interactome of PCBP1
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-2911
Abstract: Background: Iron is essential for cellular function. Homeostasis of iron is controlled post-transcriptionally via highly conserved mechanisms. We recently found broad changes in alternative splicing with reduced iron availability, consistent with numerous operant mechanisms of… read more here.
Keywords: iron; l2fc 21h7; iron levels; pcbp1 ... See more keywords
Poly(rC) binding protein 1 represses the translation of STAT3 through 5' UTR.
Sign Up to like & getrecommendations! Published in 2022 at "Current gene therapy"
DOI: 10.2174/1566523222666220511162934
Abstract: BACKGROUND Signal transducer and activator of transcription 3 (STAT3) is an oncogene and frequently overexpressed in cancers. However, the regulatory mechanisms of STAT3 expression are not fully understood. Poly(rC)-binding protein1 (PCBP1) is an RNA-binding protein… read more here.
Keywords: stat3; expression; pcbp1; poly binding ... See more keywords
Poly C Binding Protein 1 Regulates p62/SQSTM1 mRNA Stability and Autophagic Degradation to Repress Tumor Progression
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.00930
Abstract: Accumulating evidence show that Poly C Binding Protein 1 (PCBP1) is deleted in distinct types of tumors as a novel tumor suppressor, but its tumor suppression mechanism remains elusive. Here, we firstly describe that downregulation… read more here.
Keywords: tumor progression; tumor; p62 sqstm1; poly binding ... See more keywords
Discovery of an 8-oxoguanine regulator PCBP1 inhibitor by virtual screening and its synergistic effects with ROS-modulating agents in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2024.1441550
Abstract: Introduction: Drugs that target reactive oxygen species (ROS) metabolism have progressed the treatment of pancreatic cancer treatment, yet their efficacy remains poor because of the adaptation of cancer cells to high concentration of ROS. Cells… read more here.
Keywords: cancer; virtual screening; pcbp1; ros modulating ... See more keywords