Programmed cell death ligands expression in phaeochromocytomas and paragangliomas: Relationship with the hypoxic response, immune evasion and malignant behavior
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DOI: 10.1080/2162402x.2017.1358332
Abstract: ABSTRACT The hypoxic response underlies the pathogenesis and malignant behavior of PCC/PGL. Regulation of PD-1 receptor-ligand signaling, a therapeutically actionable driver of the anti-tumor immune response, is a hypoxic-driven trait across malignancies. We evaluated the… read more here.
Keywords: pcc pgl; response; expression; ligands expression ... See more keywords
Pheochromocytomas and paragangliomas in humans and dogs
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DOI: 10.1111/vco.12291
Abstract: Pheochromocytomas (PCCs) and paragangliomas (PGLs) are described in several species. In humans and dogs they have many similarities: the excessive catecholamine release in hormonally active PCC causes similar clinical signs, the frequency of metastasis is… read more here.
Keywords: pcc pgl; pcc; pheochromocytomas paragangliomas; humans dogs ... See more keywords
Germline SDHB and SDHD mutations in pheochromocytoma and paraganglioma patients
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DOI: 10.1530/ec-18-0325
Abstract: Pheochromocytoma and paragangliomas (PCC/PGL) are neuroendocrine tumors that arise from chromaffin cells of the adrenal medulla and sympathetic/parasympathetic ganglia, respectively. Of clinical relevance regarding diagnosis is the highly variable presentation of symptoms in PCC/PGL patients.… read more here.
Keywords: pcc pgl; pgl patients; germline sdhb; expression ... See more keywords
11C-hydroxy-ephedrine-PET/CT in the Diagnosis of Pheochromocytoma and Paraganglioma
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DOI: 10.3390/cancers11060847
Abstract: Pheochromocytomas (PCC) and paragangliomas (PGL) may be difficult to diagnose because of vague and uncharacteristic symptoms and equivocal biochemical and radiological findings. This was a retrospective cohort study in 102 patients undergoing 11C-hydroxy-ephedrine (11C-HED)-PET/CT because… read more here.
Keywords: pcc pgl; 11c hydroxy; pet; 11c hed ... See more keywords
Characteristics of Pediatric Pheochromocytoma/paraganglioma
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DOI: 10.4103/ijem.ijem_558_16
Abstract: The “rule of 10” used to describe pheochromocytoma/paragangliomas (PCC/PGLs) has been challenged. However, recent studies suggested that pediatric PCC/PGLs may follow a pattern. Hence, we reviewed the available literature to verify the same. We searched… read more here.
Keywords: pcc pgl; pcc pgls; pcc; pediatric pcc ... See more keywords