PCIF1-mediated deposition of 5′-cap N6,2′-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection
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DOI: 10.1073/pnas.2210361120
Abstract: Significance Understanding the molecular mechanisms of SARS-CoV-2 viral pathogenesis and developing novel inhibitors are essential and urgent. Using genome-wide N6,2′-O-dimethyladenosine (m6Am)-exo-seq, RNA-seq analysis, and CRISPR/Cas9 genome editing, we discovered that phosphorylated CTD-interacting factor 1 (PCIF1),… read more here.
Keywords: infection; pcif1; cap; ace2 tmprss2 ... See more keywords