Inhibition of Mast Cell Degranulation With Cromolyn Sodium Exhibits Organ-Specific Effects in Polycystic Kidney (PCK) Rats
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DOI: 10.1177/1091581818777754
Abstract: Autosomal recessive polycystic kidney disease (ARPKD) is a monogenic disease characterized by development of hepatorenal cysts, pericystic fibrosis, and inflammation. Previous studies show that mast cell (MC) mediators such as histamine induce proliferation of cholangiocytes.… read more here.
Keywords: treatment; cyst; polycystic kidney; pck rats ... See more keywords
Modulation of P2X4 receptor activity by ivermectin and 5‐BDBD has no effect on the development of ARPKD in PCK rats
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DOI: 10.14814/phy2.15510
Abstract: Autosomal recessive polycystic kidney disease (ARPKD) is an inherited pathology caused mainly by mutations of the polycystic kidney and hepatic disease 1 (PKHD1) gene, which usually leads to end‐stage renal disease. Previous studies suggested that… read more here.
Keywords: arpkd pck; pck rats; pck; development arpkd ... See more keywords
Everolimus halts hepatic cystogenesis in a rodent model of polycystic-liver-disease
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DOI: 10.3748/wjg.v23.i30.5499
Abstract: AIM To develop a MRI-based method for accurate determination of liver volume (LV) and to explore the effect of long-term everolimus (EVR) treatment on LV in PCK rats with hepatomegaly. METHODS Thirty-one female PCK rats… read more here.
Keywords: polycystic liver; everolimus; disease; liver ... See more keywords