Overcoming chemoresistance to b-raf inhibitor in melanoma via targeted inhibition of phosphoenolpyruvate carboxykinase1 using 3-mercaptopropionic acid
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2080385
Abstract: ABSTRACT The resistance of melanoma to BRAF inhibitors remains a tough clinical challenge. In order to explore the underlying mechanism of drug resistance in melanoma, we established the resistant cell line to vemurafenib, and assessed… read more here.
Keywords: mercaptopropionic acid; melanoma; pck1; phosphoenolpyruvate carboxykinase1 ... See more keywords
Cytosolic phosphoenolpyruvate carboxykinase is a response gene involved in porcine adipocyte adaptation to heat stress.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of animal science"
DOI: 10.1093/jas/sky126
Abstract: Heat stress (HS) leads to increased lipid storage and expression of cytosolic phosphoenolpyruvate carboxykinase (PCK1) in pig adipocytes. However, the importance of PCK1 activation and lipid storage in the adaptive response to HS is unknown.… read more here.
Keywords: cytosolic phosphoenolpyruvate; response; heat stress; pck1 ... See more keywords
Hypoxia Promotes Breast Cancer Cell Growth by Activating a Glycogen Metabolic Program
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-0753
Abstract: Hypoxic breast cancer cells trigger self-growth through PCK1-mediated glycogen metabolism reprogramming that leads to NADPH production to maintain a moderate ROS level. Hypoxia is known to be commonly present in breast tumor microenvironments. Stem-like cells… read more here.
Keywords: hypoxia; growth; cancer; breast cancer ... See more keywords
MiR-93-5P Represses the Gluconeogenesis of Hepatocellular Carcinoma while Boosting Its Glycolysis and Malignant Progression by Suppressing PCK1.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in eukaryotic gene expression"
DOI: 10.1615/critreveukaryotgeneexpr.2021038907
Abstract: Herein, we explored effects of miR-93-5p and gluconeogenic rate-limiting enzyme PCK1 on HCC cells. Bioinformatics analysis and cell experiments confirmed that, compared with expression in normal tissue and cells, miR-93-5p in HCC was abnormally upregulated… read more here.
Keywords: cell; hcc; expression; pck1 ... See more keywords
DNA methylation of pck1 might contribute to the programming effects of early high-carbohydrate diets feeding to the glucose metabolism across two generations in zebrafish (Danio rerio).
Sign Up to like & getrecommendations! Published in 2022 at "Fish physiology and biochemistry"
DOI: 10.21203/rs.3.rs-1272056/v1
Abstract: The purpose of this study is to assess the effects of early high-carbohydrate stimulus on glucose metabolism in zebrafish (Danio rerio) over two generations and explore the mechanisms that explain those nutritional programming effects via… read more here.
Keywords: high carbohydrate; glucose metabolism; pck1; carbohydrate ... See more keywords