Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma
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DOI: 10.1038/onc.2016.520
Abstract: For cancer cells to proliferate, a balance must be built between biomass-forming, glucose-metabolized intermediates and ATP production. How intrinsic glucose carbon flow regulates this balance remains unclear. Here we show that mitochondrial phosphoenolpyruvate carboxykinase (PCK2),… read more here.
Keywords: tumor repopulating; carbon; pck2; tricarboxylic acid ... See more keywords
Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18787
Abstract: Tumor-initiating cells (TICs) play important roles in tumor progression and metastasis. Identifying the factors regulating TICs may open new avenues in cancer therapy. Here, we show that TIC-enriched prostate cancer cell clones use more glucose… read more here.
Keywords: cancer; pck2; tumor initiation; prostate cancer ... See more keywords
PGC-1β and ERRα Promote Glutamine Metabolism and Colorectal Cancer Survival via Transcriptional Upregulation of PCK2
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DOI: 10.3390/cancers14194879
Abstract: Previous studies have shown that Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1β (PGC-1β) and Estrogen-Related Receptor alpha (ERRα) are over-expressed in colorectal cancer to promote tumor survival. In this study, we show that amino acid motif… read more here.
Keywords: glutamine metabolism; pck2; colorectal cancer; pgc err ... See more keywords
Role of PCK2 in the proliferation of vascular smooth muscle cells in neointimal hyperplasia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.75577
Abstract: Vascular smooth muscle cell (VSMC) proliferation is a hallmark of neointimal hyperplasia (NIH) in atherosclerosis and restenosis post-balloon angioplasty and stent insertion. Although numerous cytotoxic and cytostatic therapeutics have been developed to reduce NIH, it… read more here.
Keywords: proliferation; vsmc proliferation; neointimal hyperplasia; vascular smooth ... See more keywords