Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.520
Abstract: For cancer cells to proliferate, a balance must be built between biomass-forming, glucose-metabolized intermediates and ATP production. How intrinsic glucose carbon flow regulates this balance remains unclear. Here we show that mitochondrial phosphoenolpyruvate carboxykinase (PCK2),… read more here.
Keywords: tumor repopulating; carbon; pck2; tricarboxylic acid ... See more keywords
Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling
Sign Up to like & getrecommendations! Published in 2024 at "Nature Chemical Biology"
DOI: 10.1038/s41589-024-01612-6
Abstract: Whether stem-cell-like cancer cells avert ferroptosis to mediate therapy resistance remains unclear. In this study, using a soft fibrin gel culture system, we found that tumor-repopulating cells (TRCs) with stem-cell-like cancer cell characteristics resist chemotherapy… read more here.
Keywords: tumor repopulating; repopulating cells; ferroptosis; pck2 ... See more keywords
Association of mitochondrial phosphoenolpyruvate carboxykinase with prognosis and immune regulation in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-64907-7
Abstract: Mitochondrial phosphoenolpyruvate carboxykinase (PCK2), a mitochondrial isoenzyme, supports the growth of cancer cells under glucose deficiency conditions in vitro. This study investigated the role and potential mechanism of PCK2 in the occurrence and development of… read more here.
Keywords: immune regulation; hepatocellular carcinoma; pck2; mitochondrial phosphoenolpyruvate ... See more keywords
PCK2 maintains intestinal homeostasis and prevents colitis by protecting antibody‐secreting cells from oxidative stress
Sign Up to like & getrecommendations! Published in 2024 at "Immunology"
DOI: 10.1111/imm.13827
Abstract: Maintaining intracellular redox balance is essential for the survival, antibody secretion, and mucosal immune homeostasis of immunoglobulin A (IgA) antibody‐secreting cells (ASCs). However, the relationship between mitochondrial metabolic enzymes and the redox balance in ASCs… read more here.
Keywords: intestinal homeostasis; antibody; antibody secreting; secreting cells ... See more keywords
Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18787
Abstract: Tumor-initiating cells (TICs) play important roles in tumor progression and metastasis. Identifying the factors regulating TICs may open new avenues in cancer therapy. Here, we show that TIC-enriched prostate cancer cell clones use more glucose… read more here.
Keywords: cancer; pck2; tumor initiation; prostate cancer ... See more keywords
PGC-1β and ERRα Promote Glutamine Metabolism and Colorectal Cancer Survival via Transcriptional Upregulation of PCK2
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194879
Abstract: Previous studies have shown that Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1β (PGC-1β) and Estrogen-Related Receptor alpha (ERRα) are over-expressed in colorectal cancer to promote tumor survival. In this study, we show that amino acid motif… read more here.
Keywords: glutamine metabolism; pck2; colorectal cancer; pgc err ... See more keywords
Role of PCK2 in the proliferation of vascular smooth muscle cells in neointimal hyperplasia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.75577
Abstract: Vascular smooth muscle cell (VSMC) proliferation is a hallmark of neointimal hyperplasia (NIH) in atherosclerosis and restenosis post-balloon angioplasty and stent insertion. Although numerous cytotoxic and cytostatic therapeutics have been developed to reduce NIH, it… read more here.
Keywords: proliferation; vsmc proliferation; neointimal hyperplasia; vascular smooth ... See more keywords