On-chip controlled synthesis of polycaprolactone nanoparticles using continuous-flow microfluidic devices
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Flow Chemistry"
DOI: 10.1007/s41981-020-00092-8
Abstract: This systematic investigation assessed the potential applications of microfluidic devices in producing a uniform size distribution of polycaprolactone (PCL) nanoparticles by applying the liquid non-solvent precipitation process. Five arrangements of microfluidic devices are fabricated with… read more here.
Keywords: pcl nanoparticles; microfluidic devices; polycaprolactone; size ... See more keywords
Efficiency of flubendazole-loaded mPEG-PCL nanoparticles: A promising formulation against the protoscoleces and cysts of Echinococcus granulosus.
Sign Up to like & getrecommendations! Published in 2018 at "Acta tropica"
DOI: 10.1016/j.actatropica.2018.08.010
Abstract: None of the existing drugs can effectively treat the human cystic echinococcosis. This study aimed to improve the efficacy of flubendazole (FLBZ) against the protoscoleces and cysts of Echinococcus granulosus by preparing polymeric FLBZ-loaded methoxy… read more here.
Keywords: pcl nanoparticles; protoscoleces cysts; mpeg pcl; loaded nanoparticles ... See more keywords
Preparation and in vitro evaluation of 5-fluorouracil-loaded PCL nanoparticles for colon cancer treatment
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Development and Technology"
DOI: 10.3109/10837450.2015.1116565
Abstract: Abstract Nanoparticles loaded with 5-fluorouracil (5-FU) for colon cancer therapies were prepared using the solvent evaporation technique, which involved lyophilization by freeze-drying. Formulations produced a substantially high encapsulation efficiency of approximately 93%. A positive correlation… read more here.
Keywords: pcl nanoparticles; loaded pcl; colon cancer;
Development and Optimization of Irinotecan-Loaded PCL Nanoparticles and Their Cytotoxicity against Primary High-Grade Glioma Cells
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13040541
Abstract: Background: High-grade gliomas (HGGs) are highly malignant tumors with a poor survival rate. The inability of free drugs to cross the blood–brain barrier and their off-target accumulation result in dose-limiting side effects. This study aimed… read more here.
Keywords: pcl nanoparticles; loaded pcl; high grade; cytotoxicity ... See more keywords