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   Articles with "pcna" as a keyword



Functional hierarchy of PCNA‐interacting motifs in DNA processing enzymes

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recommendations! Published in 2023 at "BioEssays"

DOI: 10.1002/bies.202300020

Abstract: Numerous eukaryotic DNA processing enzymes, such as DNA polymerases and ligases, bind the processivity factor PCNA, which acts as a platform to recruit and regulate the binding of enzymes to their DNA substrate. Multiple PCNA‐interacting… read more here.

Keywords: pcna; dna processing; dna; pcna interacting ... See more keywords
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The PCNA interaction motifs revisited: thinking outside the PIP-box

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recommendations! Published in 2019 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-019-03150-0

Abstract: Proliferating cell nuclear antigen (PCNA) is a cellular hub in DNA metabolism and a potential drug target. Its binding partners carry a short linear motif (SLiM) known as the PCNA-interacting protein-box (PIP-box), but sequence-divergent motifs… read more here.

Keywords: pcna; pcna interaction; pip box; affinity ... See more keywords

In silico profiling and structural insights of zinc metal ion on O6-methylguanine methyl transferase and its interactions using molecular dynamics approach

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recommendations! Published in 2021 at "Journal of Molecular Modeling"

DOI: 10.1007/s00894-020-04631-x

Abstract: O6-methylguanine DNA methyl transferase (MGMT) is a metalloenzyme participating in the repair of alkylated DNA. In this research, we performed a comparative study for evaluating the impact of zinc metal ion on the behavior and… read more here.

Keywords: pcna; dna; apo mgmt; mgmt ... See more keywords

Interaction of eukaryotic proliferating cell nuclear antigen (PCNA) with the replication-associated protein (Rep) of cotton leaf curl Multan virus and pedilanthus leaf curl virus

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recommendations! Published in 2021 at "3 Biotech"

DOI: 10.1007/s13205-020-02499-5

Abstract: The replication-associated (Rep) proteins of pathogenic begomoviruses, including cotton leaf curl Multan virus (CLCuMuV) and pedilanthus leaf curl virus (PeLCV), interact with the DNA replication machinery of their eukaryotic hosts. The analysis of Rep protein… read more here.

Keywords: pcna; leaf curl; leaf; replication ... See more keywords

An environment-friendly route to synthesize pyramid-like g-C3N4 arrays for efficient degradation of rhodamine B under visible-light irradiation

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recommendations! Published in 2018 at "Chemical Engineering Journal"

DOI: 10.1016/j.cej.2017.11.133

Abstract: Abstract Pyramid-like g-C3N4 arrays (PCNA) were successfully prepared for the first time by ultra-rapid microwave heating method. The as-synthesized PCNA was investigated by comprehensive analytical techniques. The ultraviolet–visible (UV–Vis) spectrum of PCNA had an absorption… read more here.

Keywords: pcna; pyramid like; visible light; c3n4 arrays ... See more keywords

A genetic study based on PCNA-ubiquitin fusions reveals no requirement for PCNA polyubiquitylation in DNA damage tolerance.

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recommendations! Published in 2017 at "DNA repair"

DOI: 10.1016/j.dnarep.2017.04.003

Abstract: Post-translational modifications of Proliferating Cell Nuclear Antigen (PCNA) play a key role in regulating the bypass of DNA lesions during DNA replication. PCNA can be monoubiquitylated at lysine 164 by the RAD6-RAD18 ubiquitin ligase complex.… read more here.

Keywords: pcna; dna damage; pcna polyubiquitylation; dna ... See more keywords
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Something's gotta give: How PCNA alters its structure in response to mutations and the implications on cellular processes.

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recommendations! Published in 2020 at "Progress in biophysics and molecular biology"

DOI: 10.1016/j.pbiomolbio.2020.10.008

Abstract: Proliferating cell nuclear antigen (PCNA) is an essential protein that regulates the systematic recruitment and activity of proteins in a multitude of biochemical processes. Very few proteins, if any, bear similar responsibilities to those of… read more here.

Keywords: pcna; give pcna; something got; structure ... See more keywords
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Structural basis of human PCNA sliding on DNA

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/ncomms13935

Abstract: Sliding clamps encircle DNA and tether polymerases and other factors to the genomic template. However, the molecular mechanism of clamp sliding on DNA is unknown. Using crystallography, NMR and molecular dynamics simulations, here we show… read more here.

Keywords: pcna; structural basis; dna; clamp ... See more keywords

ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-13667-4

Abstract: Maintaining stability of replication forks is important for genomic integrity. However, it is not clear how replisome proteins contribute to fork stability under replication stress. Here, we report that ATAD5, a PCNA unloader, plays multiple… read more here.

Keywords: pcna; restart; atad5; replication stress ... See more keywords

Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-59323-y

Abstract: FAN1 is a DNA dependent nuclease whose proper function is essential for maintaining human health. For example, a genetic variant in FAN1, Arg507 to His hastens onset of Huntington’s disease, a repeat expansion disorder for… read more here.

Keywords: pcna; function; fan1 nuclease; molecular basis ... See more keywords

Ubiquitin protease Ubp1 cooperates with Ubp10 and Ubp12 to revert lysine-164 PCNA ubiquitylation at replication forks

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf076

Abstract: Abstract Proliferating cell nuclear antigen (PCNA) is essential for the faithful duplication of eukaryotic genomes. PCNA also orchestrates events necessary to address threats to genomic integrity, such as the DNA damage tolerance (DDT) response, a… read more here.

Keywords: replication; ubp10 ubp12; pcna; ubiquitylation ... See more keywords