Proton beam therapy for adolescent primary central nervous system lymphoma with residual tumor after intensive chemotherapy: a case report.
Sign Up to like & getrecommendations! Published in 2019 at "Practical radiation oncology"
DOI: 10.1016/j.prro.2019.05.005
Abstract: Primary central nervous system lymphoma (PCNSL) is a very rare type of non-Hodgkin lymphoma. Although pediatric and adolescent PCNSL patients generally respond well to intensive chemotherapy, the salvage treatment for this condition remains uncertain for… read more here.
Keywords: chemotherapy; residual tumor; intensive chemotherapy; pcnsl ... See more keywords
Immunochemotherapy using rituximab (RTX) and high-dose methotrexate (HD-MTX): an evaluation of the addition of RTX to HD-MTX in recurrent primary central nervous system lymphoma (PCNSL)
Sign Up to like & getrecommendations! Published in 2017 at "Japanese Journal of Clinical Oncology"
DOI: 10.1093/jjco/hyx095
Abstract: Background There is increasing evidence that MTX-based chemotherapy is superior to HD-MTX alone. Rituximab (RTX) is effective in a variety of B-cell lymphomas and may enter the brain. The purpose of this study is to… read more here.
Keywords: addition rtx; rtx mtx; group; pcnsl ... See more keywords
BIOM-54. A RAPID GENOTYPING PANEL FOR SENSITIVE AND SPECIFIC SEGREGATION OF CNS PATHOLOGIES
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DOI: 10.1093/neuonc/noaa215.051
Abstract: Primary central nervous system lymphoma (PCNSL) remains challenging to diagnose due to nonspecific clinical and radiologic features and low diagnostic yields of cerebrospinal fluid (CSF) studies. We sought to characterize the diagnostic approach of suspected… read more here.
Keywords: glioma; biom rapid; csf; pcnsl ... See more keywords
P05.04 Phase 2 open-label study of maintenance treatment with ibrutinib following first line methotrexate-based immuno-chemotherapy in elderly patients with primary CNS lymphoma (PCNSL)
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DOI: 10.1093/neuonc/noz126.118
Abstract: Patients older than 60 years account for up to 70% of all PCNSL cases. Elderly PCNSL patients have median overall survival (OS) under 2 years and progression free survival (PFS) ranging between 6–16 months. Older… read more here.
Keywords: methotrexate based; first line; maintenance; treatment ... See more keywords
P14.90 Interleukin 6 is a useful marker for pseudotumoral inflammatory CNS lesions suspicious of lymphoma
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DOI: 10.1093/neuonc/noz126.325
Abstract: Interleukin (IL)-6 is a dual pro and anti-inflammatory cytokine and its presence in the cerebrospinal fluid (CSF) is considered as a marker of central nervous system (CNS) inflammation. Our aim was to analyze the diagnostic… read more here.
Keywords: pseudotumoral inflammatory; group; cns; csf ... See more keywords
ACTR-23. MAINTENANCE TREATMENT WITH IBRUTINIB FOLLOWING FIRST LINE METHOTREXATE-BASED IMMUNO-CHEMOTHERAPY IN ELDERLY PATIENTS WITH PRIMARY CNS LYMPHOMA (PCNSL). A PHASE 2 OPEN-LABEL STUDY
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DOI: 10.1093/neuonc/noz175.066
Abstract: Patients older than 60 years account for up to 70% of all PCNSL cases. Elderly PCNSL patients have median overall survival (OS) under 2 years and progression free survival (PFS) ranging between 6–16 months. Older… read more here.
Keywords: first line; maintenance; treatment; study ... See more keywords
Primary central nervous system lymphoma: advances in its pathogenesis, molecular markers and targeted therapies
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Neurology"
DOI: 10.1097/wco.0000000000001115
Abstract: Purpose of review Primary central nervous system lymphoma (PCNSL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL) located in the CNS with a less favorable prognosis. Recent information addressing the disease molecular heterogeneity… read more here.
Keywords: primary central; central nervous; system lymphoma; pathogenesis ... See more keywords
Primary central nervous system lymphoma in the United States, 1975–2017
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DOI: 10.1177/20406207211066166
Abstract: Background: Primary central nervous system lymphoma (PCNSL) has received more attention because of an inferior prognosis. Less is known about the incidence rate, histological type, and survival rate of PCNSL, especially in the 2010s. Methods:… read more here.
Keywords: survival; rate; central nervous; incidence ... See more keywords
Ifosphamide and Carboplatin Based (R-DeVIC) Salvage Therapy in Patients with Relapsed/Refractory PCNSL - a Multicentre Retrospective Analysis
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DOI: 10.1182/blood-2018-99-117329
Abstract: Background Primary central nervous system lymphoma (PCNSL) is rare and aggressive Non-Hodgkin lymphoma of the central nervous system (CNS).High-dose methotrexate (HD-MTX) based chemotherapy is standard first-line treatment in newly diagnosed disease. Although remissions can be… read more here.
Keywords: relapsed refractory; consultancy honoraria; treatment; pcnsl ... See more keywords
EBV-tissue positive primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity.
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DOI: 10.1182/blood.2020008520
Abstract: Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the context of immunosuppression, e.g. post-transplant lymphoproliferative disorders (PTLD) or HIV… read more here.
Keywords: ebv tissue; ebv hiv; pcnsl; tissue positive ... See more keywords
Management and outcome of primary CNS lymphoma in the modern era
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DOI: 10.1212/wnl.0000000000008900
Abstract: Objective Real-life studies on patients with primary CNS lymphoma (PCNSL) are scarce. Our objective was to analyze, in a nationwide population-based study, the current medical practice in the management of PCNSL. Methods The French oculo-cerebral… read more here.
Keywords: management; cns lymphoma; lymphoma; hct asct ... See more keywords