Efficacy and safety of the R2-MTX regimen in primary central nervous system lymphoma (PCNSL): a single-center retrospective analysis
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DOI: 10.1007/s00432-025-06205-x
Abstract: Primary central nervous system lymphoma (PCNSL) has a poor prognosis, mainly because of the significant challenges with the efficacy and tolerability of induction chemotherapy. This retrospective study aimed to evaluate the efficacy and safety of… read more here.
Keywords: central nervous; mtx regimen; analysis; primary central ... See more keywords
Proton beam therapy for adolescent primary central nervous system lymphoma with residual tumor after intensive chemotherapy: a case report.
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DOI: 10.1016/j.prro.2019.05.005
Abstract: Primary central nervous system lymphoma (PCNSL) is a very rare type of non-Hodgkin lymphoma. Although pediatric and adolescent PCNSL patients generally respond well to intensive chemotherapy, the salvage treatment for this condition remains uncertain for… read more here.
Keywords: chemotherapy; residual tumor; intensive chemotherapy; pcnsl ... See more keywords
Immunochemotherapy using rituximab (RTX) and high-dose methotrexate (HD-MTX): an evaluation of the addition of RTX to HD-MTX in recurrent primary central nervous system lymphoma (PCNSL)
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DOI: 10.1093/jjco/hyx095
Abstract: Background There is increasing evidence that MTX-based chemotherapy is superior to HD-MTX alone. Rituximab (RTX) is effective in a variety of B-cell lymphomas and may enter the brain. The purpose of this study is to… read more here.
Keywords: addition rtx; rtx mtx; group; pcnsl ... See more keywords
BIOM-54. A RAPID GENOTYPING PANEL FOR SENSITIVE AND SPECIFIC SEGREGATION OF CNS PATHOLOGIES
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DOI: 10.1093/neuonc/noaa215.051
Abstract: Primary central nervous system lymphoma (PCNSL) remains challenging to diagnose due to nonspecific clinical and radiologic features and low diagnostic yields of cerebrospinal fluid (CSF) studies. We sought to characterize the diagnostic approach of suspected… read more here.
Keywords: glioma; biom rapid; csf; pcnsl ... See more keywords
THE UTILITY OF MULTIPARAMETRIC MRI IN REDUCING DIAGNOSTIC UNCERTAINTY FOR PRIMARY CNS LYMPHOMA
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DOI: 10.1093/neuonc/noae158.083
Abstract: A key limitation in the early treatment initiation in primary central nervous system lymphoma (PCNSL) is the diagnostic delay caused by lack of recognition of a lesion as a possible lymphoma, steroid initiation, and lesion… read more here.
Keywords: reducing diagnostic; mri; diagnostic uncertainty; lymphoma ... See more keywords
P14.04.A CHARACTERISTIC FEATURES OF PATIENTS WITH AUTOIMMUNE DIFFERENTIAL DIAGNOSES FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA (PCNSL)
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DOI: 10.1093/neuonc/noaf193.465
Abstract: The diagnosis of this rare subtype of B-cell non-Hodgkin’s lymphoma limited to the CNS includes magnetic resonance imaging (MRI), tissue biopsy, cerebrospinal fluid (CSF) analysis and systemic staging. In imaging, PCNSL may resemble a number… read more here.
Keywords: differential diagnoses; history; positive mcdonald; mcdonald criteria ... See more keywords
P14.10.A DISTINCT EPIGENETIC AND TRANSCRIPTIONAL PROFILES OF EPSTEIN-BARR VIRUS (EBV) POSITIVE AND NEGATIVE PRIMARY CNS LYMPHOMAS
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DOI: 10.1093/neuonc/noaf193.471
Abstract: Epstein-Barr virus (EBV)+ and EBV- primary CNS lymphomas (PCNSL) carry distinct mutational landscapes, but their transcriptional and epigenetic profiles have not been integrated and compared. This precludes further insights into pathobiology and molecular differences, relevant… read more here.
Keywords: epstein barr; ebv; ebv pcnsl; ebv ebv ... See more keywords
INNV-12. Clinical utility of repeat brain biopsy in recurrent or refractory primary CNS lymphoma – a diagnostic dilemma
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DOI: 10.1093/neuonc/noaf201.0901
Abstract: Despite advancements in therapy and improved survival rates for patients with primary central nervous system lymphoma (PCNSL), the optimal management strategy for recurrent or refractory PCNSL (r/r PCNSL) remains undefined. In such cases, repeat brain… read more here.
Keywords: brain biopsy; biopsy; repeat brain; pcnsl ... See more keywords
EXTH-11. Development of Topically Applied Fluorescent Probes for Intraoperative Diagnosis of Primary Central Nervous System Lymphoma
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DOI: 10.1093/neuonc/noaf201.1345
Abstract: Ring-enhancing lesions observed on gadolinium-enhanced MRI often include primary central nervous system lymphoma (PCNSL), metastatic brain tumors, and glioblastoma. Preoperative differentiation of these lesions remains challenging. As surgical strategies vary depending on the diagnosis, accurate… read more here.
Keywords: diagnosis; fluorescent probes; fluorescence intensity; primary central ... See more keywords
P05.04 Phase 2 open-label study of maintenance treatment with ibrutinib following first line methotrexate-based immuno-chemotherapy in elderly patients with primary CNS lymphoma (PCNSL)
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DOI: 10.1093/neuonc/noz126.118
Abstract: Patients older than 60 years account for up to 70% of all PCNSL cases. Elderly PCNSL patients have median overall survival (OS) under 2 years and progression free survival (PFS) ranging between 6–16 months. Older… read more here.
Keywords: methotrexate based; first line; maintenance; treatment ... See more keywords
P14.90 Interleukin 6 is a useful marker for pseudotumoral inflammatory CNS lesions suspicious of lymphoma
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DOI: 10.1093/neuonc/noz126.325
Abstract: Interleukin (IL)-6 is a dual pro and anti-inflammatory cytokine and its presence in the cerebrospinal fluid (CSF) is considered as a marker of central nervous system (CNS) inflammation. Our aim was to analyze the diagnostic… read more here.
Keywords: pseudotumoral inflammatory; group; cns; csf ... See more keywords