Long noncoding RNA NEAT1 decreases polycystic ovary syndrome progression via the modulation of the microRNA‐324‐3p and BRD3 axis
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DOI: 10.1002/cbin.11893
Abstract: Long noncoding RNA nuclear‐enriched abundant transcript 1 (NEAT1) is believed to be involved in many gynecological and obstetrics disorders. Nevertheless, the role of NEAT1 in polycystic ovary syndrome (PCOS) is scarcely investigated. Our study aimed… read more here.
Keywords: pcos mice; neat1; long noncoding; 324 brd3 ... See more keywords
PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA‐induced granulosa cell apoptosis in vitro
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DOI: 10.1002/ddr.22027
Abstract: This study was implemented to address the role of Roflumilast in polycystic ovary syndrome (PCOS) as well as to discuss its reaction mechanism in vivo and in vitro. In vivo, mice were administrated with 6 mg… read more here.
Keywords: dhea induced; pcos mice; lipid accumulation; mice ... See more keywords
MON-231 Dietary Interventions Can Ameliorate Polycystic Ovary Syndrome (PCOS) Traits in a PCOS Mouse Model
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DOI: 10.1210/js.2019-mon-231
Abstract: Abstract Polycystic ovary syndrome (PCOS) is a complex, heterogeneous disorder characterized by reproductive, endocrine and metabolic abnormalities; however, its aetiology is unknown and current medical management relies solely on symptomatic treatment. Hyperandrogenism is a defining… read more here.
Keywords: mice; pcos; dietary interventions; polycystic ovary ... See more keywords
E. coli Nissle 1917 ameliorates mitochondrial injury of granulosa cells in polycystic ovary syndrome through promoting gut immune factor IL-22 via gut microbiota and microbial metabolism
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DOI: 10.3389/fimmu.2023.1137089
Abstract: Objective Gut microbiota and its metabolites have regulatory effects on PCOS related ovarian dysfunction and insulin resistance. Escherichia coli Nissle 1917 (EcN) is a genetically controlled probiotic with an excellent human safety record for improving… read more here.
Keywords: metabolism; gut; pcos mice; gut microbiota ... See more keywords