Tying Reimbursement to Outcomes Is an Ideal Strategy for PCSK9 Inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Cardiology"
DOI: 10.1001/jamacardio.2017.2959
Abstract: Overview Pay-for-performance programs, which seek to better align incentives between insurers and clinicians, are increasingly being used to improve quality without necessarily increasing spending. For example, under Medicare’s hospital value-based payment program, reimbursements are based… read more here.
Keywords: pcsk9 inhibitors; based pricing; outcomes based; reimbursement ... See more keywords
Physiology and role of PCSK9 in vascular disease: Potential impact of localized PCSK9 in vascular wall
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30025
Abstract: Proprotein convertase subtilisin/kexin type‐9 (PCSK9), a member of the proprotein convertase family, is an important drug target because of its crucial role in lipid metabolism. Emerging evidence suggests a direct role of localized PCSK9 in… read more here.
Keywords: vascular disease; physiology; role; pcsk9 ... See more keywords
Physiological and therapeutic regulation of PCSK9 activity in cardiovascular disease
Sign Up to like & getrecommendations! Published in 2017 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-017-0619-0
Abstract: Ischemic heart disease is the main cause of death worldwide and is accelerated by increased levels of low-density lipoprotein cholesterol (LDL-C). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a potent circulating regulator of LDL-C through… read more here.
Keywords: regulation pcsk9; pcsk9 activity; pcsk9; disease ... See more keywords
Statin Pharmacology Revisited
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-020-06951-9
Abstract: We read with interest the review on statins by Azemawah and colleagues, but we considered that there were certain important errors and omissions [1]. The authors provided several conflicting statements about the association of new… read more here.
Keywords: risk; study; statin; drug ... See more keywords
Economic Evaluation of the PCSK9 Inhibitors in Prevention of the Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2018 at "Current Cardiology Reports"
DOI: 10.1007/s11886-018-0993-8
Abstract: Purpose of ReviewThis review aims to explore and summarize the current literature on the cardiovascular disease (CVD) healthcare burden and determine the cost-effectiveness of the PCSK9 inhibitors.Recent FindingsThe CVD remain the largest cause of mortality… read more here.
Keywords: cost effectiveness; pcsk9 inhibitors; pcsk9; cvd ... See more keywords
The New Face of Hyperlipidemia and the Role of PCSK9 Inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Current Cardiology Reports"
DOI: 10.1007/s11886-019-1103-2
Abstract: Purpose of ReviewTo review the clinical rationale for use of proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors in clinical practice.Recent FindingsDespite widespread use of statins for lipid lowering, many patients at high cardiovascular risk… read more here.
Keywords: new face; risk; pcsk9 inhibitors; face hyperlipidemia ... See more keywords
Outcomes, Access, and Cost Issues Involving PCSK9 Inhibitors to Lower LDL-Cholesterol
Sign Up to like & getrecommendations! Published in 2018 at "Drugs"
DOI: 10.1007/s40265-018-0867-9
Abstract: The clinical importance and benefit of the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors appears well established for the high-risk cardiovascular (CV) patient. This applies especially to the statin-intolerant patient or the patient who does… read more here.
Keywords: outcomes access; pcsk9 inhibitors; ldl; cholesterol ... See more keywords
Vaccines Targeting PCSK9: A Promising Alternative to Passive Immunization with Monoclonal Antibodies in the Management of Hyperlipidaemia?
Sign Up to like & getrecommendations! Published in 2018 at "Drugs"
DOI: 10.1007/s40265-018-0915-5
Abstract: Hypercholesterolaemia is frequently observed in patients with cardiovascular diseases (CVD) and is associated with increased mortality. Statin treatment has been the standard of care for reducing low-density lipoprotein cholesterol (LDL-C) to improve cardiovascular outcomes. However,… read more here.
Keywords: monoclonal antibodies; vaccines targeting; targeting pcsk9; pcsk9 ... See more keywords
A systematic review of LDLR, PCSK9, and APOB variants in Asia.
Sign Up to like & getrecommendations! Published in 2020 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2020.05.004
Abstract: BACKGROUND AND AIMS Genetic identification is a public health care concern for management of familial hypercholesterolemia (FH) associated cardiovascular morbidity and mortality. This study presents the spectrum and distribution of LDLR, APOB, PCSK9 gene mutations… read more here.
Keywords: apob; systematic review; review ldlr; pcsk9 ... See more keywords
PCSK9 post-transcriptional regulation: Role of a 3'UTR microRNA-binding site variant in linkage disequilibrium with c.1420G.
Sign Up to like & getrecommendations! Published in 2020 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2020.10.010
Abstract: BACKGROUND AND AIMS Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a crucial role in cholesterol homeostasis. A common variant, the G allele in position c.1420 (c.1420G), has been associated with a decrease of both plasma… read more here.
Keywords: transcriptional regulation; hsa mir; post transcriptional; pcsk9 ... See more keywords
PCSK9 promotes arterial medial calcification.
Sign Up to like & getrecommendations! Published in 2022 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2022.01.015
Abstract: BACKGROUND AND AIMS A complex interplay among chronic kidney disease (CKD), lipid metabolism and aortic calcification has been recognized. Here we investigated the influence of kidney function on PCSK9 levels and its potential direct action… read more here.
Keywords: pcsk9; promotes arterial; calcification; pro calcific ... See more keywords