Serum PCSK9 levels at the second nivolumab cycle predict overall survival in elderly patients with NSCLC: a pilot study
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02367-z
Abstract: Monoclonal antibodies targeting PD-1 are used for treating NSCLC. To date, proprotein convertase subtilisin/kexin type 9 (PCSK9) has been poorly investigated in the oncologic field. Here, we aimed at evaluating whether serum PCSK9 might represent… read more here.
Keywords: pilot study; study; cycle; pcsk9 levels ... See more keywords
PCSK9 and Lp(a) levels of children born after assisted reproduction technologies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-019-01474-1
Abstract: PurposeProprotein convertase subtilisin/kexin type 9 (PCSK9) and lipoprotein (a) (Lp[a]) levels are associated with cardiovascular risk. To investigate PCSK9 and Lp(a) levels of children born after assisted reproduction technologies (ART) compared with naturally conceived (NC)… read more here.
Keywords: age; pcsk9 levels; levels children; assisted reproduction ... See more keywords
Circulating levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) are associated with monocyte subsets in patients with stable coronary artery disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2021.02.005
Abstract: BACKGROUND Proprotein convertase subtilisin/kexin type-9 (PCSK9) is an enzyme promoting the degradation of low-density lipoprotein receptors (LDL-R) in hepatocytes. Inhibition of PCSK9 has emerged as a novel target for lipid-lowering therapy. Monocytes are crucially involved… read more here.
Keywords: proprotein convertase; disease; monocyte subsets; pcsk9 levels ... See more keywords
Increased serum PCSK9 levels are associated with renal function impairment in patients with type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2023 at "Renal Failure"
DOI: 10.1080/0886022x.2023.2215880
Abstract: Abstract Purpose The purpose of this study was to investigate the association between serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels and renal function impairment in type 2 diabetes mellitus (T2DM) patients. Methods PCSK9 levels… read more here.
Keywords: serum pcsk9; pcsk9; pcsk9 tertile; renal function ... See more keywords
Prognostic value of PCSK9 Levels in Non-ST elevation myocardial infarction patients undergoing percutaneous coronary intervention
Sign Up to like & getrecommendations! Published in 2021 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehab724.1376
Abstract: The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in predicting major adverse cardiovascular events (MACEs) in Non-ST elevation myocardial infarction (NSTEMI) patients is still an open question and the PCSK9 concentration of clinical usefulness… read more here.
Keywords: myocardial infarction; elevation myocardial; non elevation; pcsk9 levels ... See more keywords
Effects of antiretroviral therapy on proprotein convertase subtilisin/kexin 9: focus on lipids, inflammation and immunovirological parameters.
Sign Up to like & getrecommendations! Published in 2020 at "HIV medicine"
DOI: 10.1111/hiv.12884
Abstract: OBJECTIVES Plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9), a major regulator of cholesterol metabolism, have been reported to have an increasing trend in people living with HIV (PLWH) compared with controls. We assessed… read more here.
Keywords: proprotein convertase; inflammation; cholesterol; pcsk9 levels ... See more keywords
The predictive utility of circulating PCSK9 levels on diabetes mellitus
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular Diabetology"
DOI: 10.1186/s12933-021-01226-5
Abstract: Increasing data including ours have suggested that proprotein convertase subtilisin/kexin type 9 (PCSK9), a novel regulator of cholesterol metabolism, may also play an important role in the development of type 2 diabetes mellitus (T2DM) and… read more here.
Keywords: t2dm; pcsk9 levels; diabetes mellitus; pcsk9 ... See more keywords
Serum PCSK9 levels, but not PCSK9 polymorphisms, are associated with CAD risk and lipid profiles in southern Chinese Han population
Sign Up to like & getrecommendations! Published in 2018 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-018-0859-5
Abstract: BackgroundGenetic and environment factors affect the occurrence and development of coronary artery disease (CAD). Proprotein convertase subtilisin/kexin type 9 (PCSK9), has been investigated extensively in the field of lipid metabolism and CAD. We performed this… read more here.
Keywords: cad; pcsk9 levels; pcsk9; population ... See more keywords
Associations Among PCSK9 Levels, Atherosclerosis-Derived Extracellular Vesicles, and Their miRNA Content in Adults With Obesity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.785250
Abstract: Background: Extracellular vesicles (EV) concentration is generally increased in patients with cardiovascular diseases, although the protective role of EVs in atherosclerosis has been reported. Among the specific cargo of EVs, miRNAs contribute to different stages… read more here.
Keywords: mirna content; associations among; extracellular vesicles; receptor ... See more keywords
Physical activity to reduce PCSK9 levels
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.988698
Abstract: The amount of physical activity (PA) people practice everyday has been reducing in the last decades. Sedentary subjects tend to have an impaired lipid plasma profile with a higher risk of atherosclerosis and related cardio-… read more here.
Keywords: activity reduce; reduce pcsk9; physical activity; pcsk9 ... See more keywords
Genome-Wide Association of Proprotein Convertase Subtilisin/Kexin Type 9 Plasma Levels in the ELSA-Brasil Study
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.728526
Abstract: Pharmacological inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9) is an established therapeutic option to treat hypercholesterolemia, and plasma PCSK9 levels have been implicated in cardiovascular disease incidence. A number of genetic variants within the… read more here.
Keywords: genome wide; proprotein convertase; association; pcsk9 levels ... See more keywords