In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels
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DOI: 10.1038/s41587-021-00933-4
Abstract: Most known pathogenic point mutations in humans are C•G to T•A substitutions, which can be directly repaired by adenine base editors (ABEs). In this study, we investigated the efficacy and safety of ABEs in the… read more here.
Keywords: base editing; pcsk9 macaques; editing pcsk9; base ... See more keywords