PCYT1A Is a Metabolic Vulnerability in Monocytic Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-202832
Abstract: Acute myeloid leukemia (AML) is a highly heterogeneous blood cancer with unique morphologic and genomic characteristics. Several genetic aberrations, such as TP53 mutations (TP53-MT) and MLL (KMT2A) rearrangements (MLL-r), are associated with inferior outcomes. The… read more here.
Keywords: monocytic aml; mll aml; aml; pcyt1a ... See more keywords
PCYT1A deficiency disturbs fatty acid metabolism and induces ferroptosis in the mouse retina
Sign Up to like & getrecommendations! Published in 2024 at "BMC Biology"
DOI: 10.1186/s12915-024-01932-y
Abstract: Inherited retinal dystrophies (IRDs) are a group of debilitating visual disorders characterized by the progressive degeneration of photoreceptors, which ultimately lead to blindness. Among the causes of this condition, mutations in the PCYT1A gene, which… read more here.
Keywords: acid metabolism; ferroptosis; retina; pcyt1a ... See more keywords