Exploiting the Innate Plasticity of the Programmed Cell Death‐1 (PD1) Receptor to Design Pembrolizumab H3 Loop Mimics **
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200449
Abstract: Checkpoint blockade of the immunoreceptor programmed cell death‐1 (PD1) with its ligand‐1 (PDL1) by monoclonal antibodies such as pembrolizumab provided compelling clinical results in various cancer types, yet the molecular mechanism by which this drug… read more here.
Keywords: cell death; death pd1; innate plasticity; pd1 ... See more keywords
PD1 and PDL1 expression in primary central nervous system diffuse large B‐cell lymphoma are frequent and expression of PD1 predicts poor survival
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2375
Abstract: Primary central nervous system diffuse large B‐cell lymphoma (PCNS‐DLBCL) is a rare and aggressive type of diffuse large B‐cell lymphoma (DLBCL) whit poorly understood pathogenesis. Finding biomarkers associated with patient survival may be important for… read more here.
Keywords: pd1; dlbcl; large cell; expression ... See more keywords
A novel bispecific chimeric PD1-DAP10/NKG2D receptor augments NK92-cell therapy efficacy for human gastric cancer SGC-7901 cell.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.01.005
Abstract: Cell-based immunotherapy continues to be a promising avenue for cancers that standard therapy has failed. Although the specificity, avidity, and efficacy of infused cells have improved, immunocytotherapy still faces substantial hurdles. To this end, we… read more here.
Keywords: pd1; therapy; sgc 7901; receptor ... See more keywords
A chimeric switch-receptor PD1-DAP10-41BB augments NK92-cell activation and killing for human lung Cancer H1299 Cell.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.02.052
Abstract: Engineered natural killer (NK) cell-based therapies have been potentially broadly applicable and exhibited promising results in clinical trials, particularly in the fight against cancers. NK cell immunotherapy however always remains variable. One major obstacle is… read more here.
Keywords: pd1 dap10; h1299; pd1; cell ... See more keywords
Better Together: B7S1 Checkpoint Blockade Synergizes with anti-PD1.
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.03.029
Abstract: T cell checkpoint blockades can produce durable clinical responses, but only some patients and cancer types respond. In this issue of Immunity, Li et al. (2018) show B7S1-B7S1R signaling additionally regulates CD8+ T cell responses by working… read more here.
Keywords: pd1; better together; checkpoint blockade; together b7s1 ... See more keywords
Protectin D1 decreases pancreatitis severity in mice by inhibiting neutrophil extracellular trap formation.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107486
Abstract: BACKGROUND Docosahexaenoic acid-derived protectin D1 (PD1) was identified critical in the resolution of inflammation in vivo, where it modulates the innate immune response and stimulates resolution. Acute pancreatitis (AP) is characterized by local pancreatic inflammation… read more here.
Keywords: pd1; neutrophil extracellular; protectin decreases; formation ... See more keywords
Epitaxial growth of Pd1−Fe films on MgO single-crystal substrate
Sign Up to like & getrecommendations! Published in 2019 at "Thin Solid Films"
DOI: 10.1016/j.tsf.2018.11.015
Abstract: Abstract In the paper we report on growth conditions, morphology, crystallographic structure and magnetic anisotropy of 20 nm thick, palladium-rich Pd1−xFex (0.01 read more here.
Keywords: pd1 films; growth; films mgo; pd1 ... See more keywords
Therapeutic efficacy of PD1/PDL1 blockade in B16 melanoma is greatly enhanced by immunization with dendritic cell-targeting lentiviral vector and protein vaccine.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.02.034
Abstract: While immune checkpoint inhibition is rapidly becoming standard of care in many solid tumors, immune checkpoint inhibitors (ICIs) fail to induce clinical responses in many patients, presumably due to insufficient numbers of tumor-specific T cells… read more here.
Keywords: pd1; pdl1; blockade; vaccine ... See more keywords
Myeloid PD1 in the frame
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Immunology"
DOI: 10.1038/s41577-020-0276-7
Abstract: T cells expressing programmed cell death 1 (PD1) have been considered the main targets of immune checkpoint blockade therapy. But a new study shows that targeting PD1 on myeloid cells reprogrammes tumour-induced myelopoiesis to favour… read more here.
Keywords: pd1; pd1 frame; myeloid pd1; immunology ... See more keywords
Matching and adjusting energy band structures of Pd-modified sulphides (ZnS, In2S3 and CuS) and improving the photocatalytic activity of CO2 photoreduction.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/c9nr10394e
Abstract: A series of Pd-modified sulphide photocatalysts (ZnS-PdX%, In2S3-PdX% and CuS-PdX%) for the photoreduction of CO2 were synthesised via a simple hydrothermal method. Here, the introduction of the -S-Pd-S- surface species onto the surface of the… read more here.
Keywords: pd1; cus; photocatalytic activity; co2 ... See more keywords
A strategy for the efficient construction of anti-PD1-based bispecific antibodies with desired IgG-like properties
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2044435
Abstract: ABSTRACT Targeting PD1/PDL1 with blocking antibodies for cancer therapy has shown promising benefits in the clinic, but only approximately 20–30% of patients develop durable clinical responses to the treatment. Bispecific antibodies (BsAbs) that combine PD1/PDL1… read more here.
Keywords: igg like; immune checkpoint; desired igg; anti pd1 ... See more keywords