Articles with "pd173074 binds" as a keyword



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The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions.

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Published in 2023 at "FEBS letters"

DOI: 10.1002/1873-3468.14675

Abstract: The architectural chromatin factor high-mobility group AT-hook 2 (HMGA2) is causally involved in several human malignancies and pathologies. HMGA2 is not expressed in most normal adult somatic cells, which renders the protein an attractive drug… read more here.

Keywords: fgfr inhibitor; dna binding; hmga2; inhibitor pd173074 ... See more keywords