Polydopamine Nanoparticles Targeting Ferroptosis Mitigate Intervertebral Disc Degeneration Via Reactive Oxygen Species Depletion, Iron Ions Chelation, and GPX4 Ubiquitination Suppression
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202207216
Abstract: Intervertebral disc degeneration (IVDD)‐induced lower back pain (LBP) is a common problem worldwide. The underlying mechanism is partially accredited to ferroptosis, based on sequencing analyses of IVDD patients from the gene expression omnibus (GEO) databases.… read more here.
Keywords: iron; disc degeneration; intervertebral disc; ferroptosis ... See more keywords
In Situ Sprayed Difunctional Gel Avoiding Microenvironments Limitations to Treat Pressure Ulcers.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202300006
Abstract: How to avoid the microenvironment limitations in the therapeutic process of pressure ulcers is still challenging. The development of a functional gel can kill bacteria and scavenge ROS, which is urgently required in the therapeutic… read more here.
Keywords: situ sprayed; sprayed difunctional; pressure ulcers; pressure ... See more keywords
Size Regulation of Polydopamine Nanoparticles by Boronic Acid and Lewis Base.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202100916
Abstract: Size regulation of polydopamine nanoparticles (PDA NPs) is vital to melanin-inspired materials. The general strategy usually focuses on tuning of the reaction parameters which could affect the dopamine (DA) monomer polymerization process, such as pH,… read more here.
Keywords: regulation polydopamine; size regulation; polydopamine nanoparticles; size ... See more keywords
Plasma-synthesized mussel-inspired gold nanoparticles promote autophagy-dependent damage-associated molecular pattern release to potentiate immunogenic cancer cell death
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Industrial and Engineering Chemistry"
DOI: 10.1016/j.jiec.2021.05.035
Abstract: Abstract The development of an efficient tumor-specific therapeutic approach, which functions against the primary tumor and also repairs the host immune system to eradicate distant tumors, remains a clinical issue. Herein, this study focuses on… read more here.
Keywords: cell death; pda nps; associated molecular; damage associated ... See more keywords
Design and Antimalarial Evaluation of Polydopamine-Modified Methyl Artelinate Nanoparticles.
Sign Up to like & getrecommendations! Published in 2024 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.4c00520
Abstract: Targeted nanodrug delivery systems are highly anticipated for the treatment of malaria. It is known that Plasmodium can induce new permeability pathways (NPPs) on the membrane of infected red blood cells (iRBCs) for their nutrient… read more here.
Keywords: pda nps; pcl pda; pda; gsh ... See more keywords
Polydopamine Nanoparticle-Based Combined Chemotherapy and Photothermal Therapy for the Treatment of Liver Cancer
Sign Up to like & getrecommendations! Published in 2024 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.4c08491
Abstract: Polydopamine nanoparticles (PDA NPs) are proposed as an anti-cancer tool against hepatocellular carcinoma through the combination of near-infrared (NIR)-mediated hyperthermia and loading with a chemotherapeutic drug, sorafenib (SRF). Cell membranes isolated from a liver cancer… read more here.
Keywords: liver cancer; pda nps; cancer; treatment liver ... See more keywords
EGFR-targeting polydopamine nanoparticles co-loaded with 5-fluorouracil, irinotecan, and leucovorin to potentially enhance metastatic colorectal cancer therapy
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-80879-0
Abstract: Despite all prevention programs, many cases of colorectal cancer (CRC) are diagnosed when they have already metastasized. Herein, chemotherapy is required, and combination of 5-fluorouracil, irinotecan, and leucovorin (FOLFIRI) is one of the first-line treatments… read more here.
Keywords: colorectal cancer; fluorouracil irinotecan; irinotecan leucovorin; pda nps ... See more keywords
Targeting mitochondria with Au-Ag@Polydopamine nanoparticles for papillary thyroid cancer therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c8bm01414k
Abstract: The incidence of papillary thyroid cancer has rapidly increased in the past decade because of the progress in modern diagnostic technology. Novel therapeutic strategies for papillary thyroid cancer (which has low malignancy) based on organelle-targeted… read more here.
Keywords: papillary thyroid; thyroid cancer; cancer; cancer therapy ... See more keywords
Dopamine-derived nanoparticles for the protection of irradiation-induced intestinal injury by maintaining intestinal homeostasis.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d1bm02026a
Abstract: Radiotherapy of abdominal and pelvic tumors almost inevitably injures the intestine by oxidative stress and causes inflammation. Regrettably, traditional radioprotective agents for irradiation (IR) induced intestinal injury suffer from challenges such as poor solubility, unsatisfactory… read more here.
Keywords: induced intestinal; irradiation induced; injury; intestinal injury ... See more keywords
In situ self-assembly of polydopamine inside injectable hydrogels: antibacterial activity and photothermal therapy for superbug-infected wound healing.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00310d
Abstract: Inspired by the mussel foot proteins, polydopamine nanoparticles (PDA NPs) are often used to design hydrogel wound dressings due to their strong wet adhesion. However, additional antibiotics or nanometal bactericides are always required to enhance… read more here.
Keywords: situ self; antibacterial activity; photothermal therapy; self assembly ... See more keywords
Combined Verapamil-Polydopamine Nanoformulation Inhibits Adhesion Formation in Achilles Tendon Injury Using Rat Model
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s377600
Abstract: Introduction Topical verapamil has been demonstrated to reduce the fibroproliferative scar. Therefore, it was hypothesized that topical verapamil could reduce adhesion formation after tendon repair. The current study aimed to examine the effects of verapamil-loaded… read more here.
Keywords: adhesion; adhesion formation; tendon injury; group ... See more keywords