An unbiased high‐throughput drug screen reveals a potential therapeutic vulnerability in the most lethal molecular subtype of pancreatic cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12743
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second leading cause of cancer‐related deaths in the United States by 2020, due in part to innate resistance to widely used chemotherapeutic agents and limited knowledge… read more here.
Keywords: cancer; drug screen; gem; pdac ... See more keywords
Targeting the ubiquitin‐proteasome system in a pancreatic cancer subtype with hyperactive MYC
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12835
Abstract: The myelocytomatosis oncogene (MYC) is an important driver in a subtype of pancreatic ductal adenocarcinoma (PDAC). However, MYC remains a challenging therapeutic target; therefore, identifying druggable synthetic lethal interactions in MYC‐active PDAC may lead to… read more here.
Keywords: pdac; hyperactive myc; proteasome system; myc ... See more keywords
Systematic exploration of the underlying mechanism of gemcitabine resistance in pancreatic adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13279
Abstract: Resistance to gemcitabine is the main challenge of chemotherapy for pancreatic ductal adenocarcinoma (PDAC). Hence, the development of a response signature to gemcitabine is essential for precision therapy of PDAC. However, existing quantitative signatures of… read more here.
Keywords: gps; resistance; gemcitabine; adenocarcinoma ... See more keywords
Pancreatic cancer-derived small extracellular vesical ezrin activates fibroblasts to exacerbate cancer metastasis through STAT3 and YAP-1 signaling pathways.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13442
Abstract: Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC), play an important role in tumorigenesis, metastasis, and chemoresistance. Tumor-derived small extracellular vesicles (sEVs), which mediate cell-to-cell communication between… read more here.
Keywords: metastasis; pdac cell; pdac; cancer ... See more keywords
Sequentially Triggered Nanoparticles with Tumor Penetration and Intelligent Drug Release for Pancreatic Cancer Therapy
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DOI: 10.1002/advs.201701070
Abstract: Abstract Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive malignancy with a five year survival rate of read more here.
Keywords: pdac; penetration; drug; cpp ... See more keywords
Targeting Super‐Enhancers via Nanoparticle‐Facilitated BRD4 and CDK7 Inhibitors Synergistically Suppresses Pancreatic Ductal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.201902926
Abstract: Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignant cancer with complex genomic variations, and no targetable genomic lesions have been found yet. Super‐enhancers (SEs) have been found to contribute to the continuous and robust… read more here.
Keywords: pdac; drug; pancreatic ductal; ductal adenocarcinoma ... See more keywords
LncRNA LUCAT1 contributes to cell proliferation and migration in human pancreatic ductal adenocarcinoma via sponging miR‐539
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2724
Abstract: Pancreatic ductal adenocarcinoma is one of the most aggressive and dreadful malignancies worldwide. Long noncoding RNAs (lncRNAs) have emerged as vital regulators in the development of human malignancies and other disorders. This study aimed to… read more here.
Keywords: cell proliferation; lncrna lucat1; cell; pdac ... See more keywords
COL11A1‐driven positive feedback loop modulates fibroblast transformation and activates pancreatic cancer progression
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biology International"
DOI: 10.1002/cbin.12009
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most common leading causes of cancer death. The cancer‐associated fibroblasts (CAFs) in the tumor microenvironment (TME) aggravate the malignant behavior of PDAC. However, it is still unknown… read more here.
Keywords: driven positive; col11a1 driven; pdac; cancer ... See more keywords
Germline BRCA2 K3326X and CHEK2 I157T mutations increase risk for sporadic pancreatic ductal adenocarcinoma
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DOI: 10.1002/ijc.32127
Abstract: Rare truncating BRCA2 K3326X (rs11571833) and pathogenic CHEK2 I157T (rs17879961) variants have previously been implicated in familial pancreatic ductal adenocarcinoma (PDAC), but not in sporadic cases. The effect of both mutations in important DNA repair… read more here.
Keywords: chek2 i157t; risk; ductal adenocarcinoma; pdac ... See more keywords
Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma
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DOI: 10.1002/ijc.33464
Abstract: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, mainly due to late diagnosis at advanced tumor stages. In this study, we aimed to identify plasma protein biomarkers for early detection of PDAC. Totally, 135 PDAC… read more here.
Keywords: protein; plasma; pdac; early detection ... See more keywords
Association between a polymorphic variant in the CDKN2B‐AS1/ANRIL gene and pancreatic cancer risk
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34383
Abstract: Genes carrying high‐penetrance germline mutations may also be associated with cancer susceptibility through common low‐penetrance genetic variants. To increase the knowledge on genetic pancreatic ductal adenocarcinoma (PDAC) aetiology, the common genetic variability of PDAC familial… read more here.
Keywords: as1 anril; cdkn2b as1; risk; association ... See more keywords