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Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.01.015
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is highly lethal. MUC4 (mucin4) is a heavily glycosylated protein aberrantly expressed in PDAC and promotes tumorigenesis via an unknown mechanism. To assess this, we genetically knocked out (KO) MUC4 in…
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Keywords:
pdac cells;
pdac;
gemcitabine resistance;
muc4 enhances ... See more keywords
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Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.02.008
Abstract: Most human cancers display high levels of heterogeneity, a feature chemotherapy [6]. The study shows that NT5C1A is strongly expressed that often impacts negatively on the response to treatments. Indeed, while radio and/or chemotherapy initially…
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Keywords:
drug resistance;
pdac cells;
pdac;
resistance pancreatic ... See more keywords
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Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101107
Abstract: Highlights • We described a straightforward and highly reproducible 3D culturing method to investigate the intercellular crosstalk between pancreatic cancer and pancreatic stellate cells (PSCs)/cancer associated fibroblasts (CAFs).• Pancreatic ductal adenocarcinoma (PDAC) is therapy resistant…
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Keywords:
pdac cells;
pancreatic ductal;
ductal adenocarcinoma;
cancer ... See more keywords
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Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.407
Abstract: Pancreatic ductal adenocarcinoma (PDAC) cells usually overexpress the epidermal growth factor receptor (EGFR); however, most are resistant to the anti-EGFR monoclonal antibody, cetuximab. In this study, we report that the molecular mechanism of resistance to…
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Keywords:
src akt;
integrin driven;
pdac cells;
active integrin ... See more keywords
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Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00942-5
Abstract: Activating mutations in the proto-oncogene KRAS are a hallmark of pancreatic ductal adenocarcinoma (PDAC), an aggressive malignancy with few effective therapeutic options. Despite efforts to develop KRAS-targeted drugs, the absolute dependence of PDAC cells on…
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Keywords:
pdac cells;
lacking kras;
pancreatic cancer;
cancer cells ... See more keywords
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Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abn4948
Abstract: The tumor microbiome is increasingly implicated in cancer progression and resistance to chemotherapy. In pancreatic ductal adenocarcinoma (PDAC), high intratumoral loads of Fusobacterium nucleatum correlate with shorter survival in patients. Here, we investigated the potential…
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Keywords:
proliferation;
infection;
pdac cells;
fusobacterium ... See more keywords
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Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2021-325811
Abstract: Objective Pancreatic ductal adenocarcinomas (PDACs) include heterogeneous mixtures of low-grade cells forming pseudoglandular structures and compact nests of high-grade cells organised in non-glandular patterns. We previously reported that low-grade PDAC cells display high expression of…
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Keywords:
grade;
expression;
pdac cells;
irf1 ... See more keywords
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Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1092
Abstract: One of the most challenging aspects of PDAC is intense therapeutic resistance towards radiotherapy. Cellular signaling pathways are tightly regulated to protect and withstand constant DNA-damaging insults. Similarly, pancreatic cancer cells are known to activate…
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Keywords:
carbon;
one carbon;
carbon metabolism;
pdac cells ... See more keywords
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Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3825
Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the lethal malignancies due to the acquisition of intrinsic or acquired resistance to chemotherapeutic drugs, such as Gemcitabine (Gem). Recent evidence revealed that calcium signaling significantly contributes…
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Keywords:
andrographis;
calcium signaling;
gem;
pdac cells ... See more keywords
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Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4614
Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest tumors in humans. PDAC has an immunosuppressive tumor microenvironment, constituting for poor immunotherapy outcomes. Lymphatic vessels (LVs) transport leukocytes and antigens from tumor peripheries to draining…
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Keywords:
anti tumor;
pdac cells;
tumor chip;
tumor ... See more keywords
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Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.panca19-c59
Abstract: The current 5-year survival rate of pancreatic ductal adenocarcinoma (PDAC) is ~8%. The dismal prognosis in PDAC reflects in part an exceptional level of resistance to available therapies. Approximately half of PDAC patients present with…
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Keywords:
pdac;
pdac cells;
radiation;
nrf2 drives ... See more keywords