MUC4 enhances gemcitabine resistance and malignant behaviour in pancreatic cancer cells expressing cancer-associated short O-glycans.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.01.015
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is highly lethal. MUC4 (mucin4) is a heavily glycosylated protein aberrantly expressed in PDAC and promotes tumorigenesis via an unknown mechanism. To assess this, we genetically knocked out (KO) MUC4 in… read more here.
Keywords: pdac cells; pdac; gemcitabine resistance; muc4 enhances ... See more keywords
Drug resistance in pancreatic cancer: New player caught in act
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DOI: 10.1016/j.ebiom.2019.02.008
Abstract: Most human cancers display high levels of heterogeneity, a feature chemotherapy [6]. The study shows that NT5C1A is strongly expressed that often impacts negatively on the response to treatments. Indeed, while radio and/or chemotherapy initially… read more here.
Keywords: drug resistance; pdac cells; pdac; resistance pancreatic ... See more keywords
3D heterospecies spheroids of pancreatic stroma and cancer cells demonstrate key phenotypes of pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101107
Abstract: Highlights • We described a straightforward and highly reproducible 3D culturing method to investigate the intercellular crosstalk between pancreatic cancer and pancreatic stellate cells (PSCs)/cancer associated fibroblasts (CAFs).• Pancreatic ductal adenocarcinoma (PDAC) is therapy resistant… read more here.
Keywords: pdac cells; pancreatic ductal; ductal adenocarcinoma; cancer ... See more keywords
Co-targeting of EGF receptor and neuropilin-1 overcomes cetuximab resistance in pancreatic ductal adenocarcinoma with integrin β1-driven Src-Akt bypass signaling
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DOI: 10.1038/onc.2016.407
Abstract: Pancreatic ductal adenocarcinoma (PDAC) cells usually overexpress the epidermal growth factor receptor (EGFR); however, most are resistant to the anti-EGFR monoclonal antibody, cetuximab. In this study, we report that the molecular mechanism of resistance to… read more here.
Keywords: src akt; integrin driven; pdac cells; active integrin ... See more keywords
Survival of pancreatic cancer cells lacking KRAS function
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DOI: 10.1038/s41467-017-00942-5
Abstract: Activating mutations in the proto-oncogene KRAS are a hallmark of pancreatic ductal adenocarcinoma (PDAC), an aggressive malignancy with few effective therapeutic options. Despite efforts to develop KRAS-targeted drugs, the absolute dependence of PDAC cells on… read more here.
Keywords: pdac cells; lacking kras; pancreatic cancer; cancer cells ... See more keywords
Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abn4948
Abstract: The tumor microbiome is increasingly implicated in cancer progression and resistance to chemotherapy. In pancreatic ductal adenocarcinoma (PDAC), high intratumoral loads of Fusobacterium nucleatum correlate with shorter survival in patients. Here, we investigated the potential… read more here.
Keywords: proliferation; infection; pdac cells; fusobacterium ... See more keywords
Interferon regulatory factor 1 (IRF1) controls the metabolic programmes of low-grade pancreatic cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2021-325811
Abstract: Objective Pancreatic ductal adenocarcinomas (PDACs) include heterogeneous mixtures of low-grade cells forming pseudoglandular structures and compact nests of high-grade cells organised in non-glandular patterns. We previously reported that low-grade PDAC cells display high expression of… read more here.
Keywords: grade; expression; pdac cells; irf1 ... See more keywords
Abstract 1092: Targeting one-carbon metabolism radiosensitizes pancreatic ductal adenocarcinoma cells (PDAC)
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1092
Abstract: One of the most challenging aspects of PDAC is intense therapeutic resistance towards radiotherapy. Cellular signaling pathways are tightly regulated to protect and withstand constant DNA-damaging insults. Similarly, pancreatic cancer cells are known to activate… read more here.
Keywords: carbon; one carbon; carbon metabolism; pdac cells ... See more keywords
Abstract 3825: Andrographis reverses gemcitabine-associated chemoresistance by regulating calcium signaling in pancreatic ductal adenocarcinoma
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DOI: 10.1158/1538-7445.am2023-3825
Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the lethal malignancies due to the acquisition of intrinsic or acquired resistance to chemotherapeutic drugs, such as Gemcitabine (Gem). Recent evidence revealed that calcium signaling significantly contributes… read more here.
Keywords: andrographis; calcium signaling; gem; pdac cells ... See more keywords
Abstract 4614: Investigating lymphatic vessel remodeling and anti-tumor immunity in pancreatic cancer using tumor-on-chip and mouse models
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DOI: 10.1158/1538-7445.am2023-4614
Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest tumors in humans. PDAC has an immunosuppressive tumor microenvironment, constituting for poor immunotherapy outcomes. Lymphatic vessels (LVs) transport leukocytes and antigens from tumor peripheries to draining… read more here.
Keywords: anti tumor; pdac cells; tumor chip; tumor ... See more keywords
Abstract C59: NRF2 drives metabolic reprogramming in irradiated pancreatic cancer cells and promotes radioresistance
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DOI: 10.1158/1538-7445.panca19-c59
Abstract: The current 5-year survival rate of pancreatic ductal adenocarcinoma (PDAC) is ~8%. The dismal prognosis in PDAC reflects in part an exceptional level of resistance to available therapies. Approximately half of PDAC patients present with… read more here.
Keywords: pdac; pdac cells; radiation; nrf2 drives ... See more keywords