Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.10.011
Abstract: Despite expression of oncogenic KRAS, premalignant pancreatic intraepithelial neoplasia 1 (PanIN1) lesions rarely become fully malignant pancreatic ductal adenocarcinoma (PDAC). The molecular mechanisms through which established risk factors, such as chronic pancreatitis, acinar cell damage,… read more here.
Keywords: stress activated; pdac; mdm2; neoplastic progression ... See more keywords
Mir34a constrains pancreatic carcinogenesis
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DOI: 10.1038/s41598-020-66561-1
Abstract: Several studies have shown that over 70 different microRNAs are aberrantly expressed in pancreatic ductal adenocarcinoma (PDAC), affecting proliferation, apoptosis, metabolism, EMT and metastasis. The most important genetic alterations driving PDAC are a constitutive active… read more here.
Keywords: pancreatic carcinogenesis; pdac; constrains pancreatic; mir34a ... See more keywords