Impact of comprehensive family history and genetic analysis in the multidisciplinary pancreatic tumor clinic setting
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5059
Abstract: Genetic testing is recommended for all pancreatic ductal adenocarcinoma (PDAC) patients. Prior research demonstrates that multidisciplinary pancreatic cancer clinics (MDPCs) improve treatment‐ and survival‐related outcomes for PDAC patients. However, limited information exists regarding the utility… read more here.
Keywords: impact comprehensive; pdac patients; comprehensive family; multidisciplinary pancreatic ... See more keywords
Immune-related somatic mutation genes are enriched in PDACs with diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2019.03.006
Abstract: The bidirectional interaction between pancreatic cancer (PanCa) and diabetes has been confirmed by epidemiological studies, but until now, the underlying molecular mechanisms for this connection is not fully understood yet. Here, we analyzed the clinical… read more here.
Keywords: pdac patients; pdacs; somatic mutation; immune related ... See more keywords
Surveillance for pancreatic cancer in high-risk individuals leads to improved outcomes: a propensity score-matched analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Gastroenterology"
DOI: 10.1053/j.gastro.2023.02.032
Abstract: BACKGROUND & AIMS Recent pancreatic cancer surveillance programs of high-risk individuals have reported improved outcomes. This study assessed to what extent outcomes of pancreatic ductal adenocarcinoma (PDAC) in patients with a CDKN2A/p16 pathogenic variant (PV)… read more here.
Keywords: surveillance patients; surveillance; pdac patients; non surveillance ... See more keywords
The impact of nutritional status on pancreatic cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2022.2026771
Abstract: ABSTRACT Introduction Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive disease with poor outcomes. One of the reasons for the dismal prognosis resides in its impressive ability to alter the nutritional status of patients who develop… read more here.
Keywords: impact nutritional; nutritional status; pdac patients; therapy ... See more keywords
High prevalence of mutant KRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients
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DOI: 10.1093/annonc/mdx004
Abstract: Background Exosomes arise from viable cancer cells and may reflect a different biology than circulating cell-free DNA (cfDNA) shed from dying tissues. We compare exosome-derived DNA (exoDNA) to cfDNA in liquid biopsies of patients with… read more here.
Keywords: pdac patients; mutant kras; early stage; cancer ... See more keywords
Circulating cancer‐associated extracellular vesicles as early detection and recurrence biomarkers for pancreatic cancer
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DOI: 10.1111/cas.15500
Abstract: Early detection of pancreatic ductal adenocarcinoma (PDAC) is essential for improving patient survival rates, and noninvasive biomarkers are urgently required to identify patients who are eligible for curative surgery. Here, we examined extracellular vesicles (EVs)… read more here.
Keywords: extracellular vesicles; pdac patients; recurrence; cancer ... See more keywords
The effect of antibiotic use on survival of patients with resected pancreatic ductal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e15773
Abstract: e15773 Background: Recent studies showed that gut microbial dysbiosis can affect carcinogenesis and tumor responses to therapies. Antibiotics, key pharmacologic agents that modulate microbiota diversity and bacterial strains, can lead to dysbiosis. Recent studies have… read more here.
Keywords: pdac patients; antibiotic use; effect; survival ... See more keywords
Are Staging Computed Tomography (CT) Scans of the Chest Necessary in Pancreatic Adenocarcinoma?
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Surgical Oncology"
DOI: 10.1245/s10434-018-6764-3
Abstract: BackgroundThere is no consensus on the use of chest imaging in pancreatic ductal adenocarcinoma (PDAC) patients. Among PDAC patients, we examined the use of chest computed tomography (CT) over time and determined whether the use… read more here.
Keywords: adenocarcinoma; computed tomography; pdac patients; staging chest ... See more keywords
Biomarkers for the risk of thrombosis in pancreatic adenocarcinoma are related to cancer process
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DOI: 10.18632/oncotarget.25458
Abstract: Background Venous thrombo-embolic events (VTE) frequently occur in patients with pancreatic ductal adenocarcinoma (PDAC) and contribute to high morbidity and mortality. Objectives To determine whether VTE biomarkers are related to cancer, inflammation or precancerous states… read more here.
Keywords: related cancer; activity; pdac patients; dimers activity ... See more keywords
Prophylactic Anticoagulation in Patients With Pancreatic Adenocarcinoma: A Single Tertiary Care Center Retrospective QI Project
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DOI: 10.21873/anticanres.16142
Abstract: Background/Aim: A well-known complication of pancreatic adenocarcinoma (PDAC) is venous thromboembolism (VTE). The Khorana score is used as a tool to help determine the role of primary prophylaxis (PPx) in cancer patients with VTE. This… read more here.
Keywords: anticoagulation; ppx; vte ppx; pdac patients ... See more keywords
Prediction of risk and overall survival of pancreatic cancer from blood soluble immune checkpoint-related proteins
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1189161
Abstract: Background Immune checkpoint inhibition holds promise as a novel treatment for pancreatic ductal adenocarcinoma (PDAC). The clinical significance of soluble immune checkpoint (ICK) related proteins have not yet fully explored in PDAC. Methods We comprehensively… read more here.
Keywords: immune checkpoint; related proteins; pdac patients; subtype ... See more keywords