Impact of comprehensive family history and genetic analysis in the multidisciplinary pancreatic tumor clinic setting
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DOI: 10.1002/cam4.5059
Abstract: Genetic testing is recommended for all pancreatic ductal adenocarcinoma (PDAC) patients. Prior research demonstrates that multidisciplinary pancreatic cancer clinics (MDPCs) improve treatment‐ and survival‐related outcomes for PDAC patients. However, limited information exists regarding the utility… read more here.
Keywords: impact comprehensive; pdac patients; comprehensive family; multidisciplinary pancreatic ... See more keywords
Novel serum protein biomarker panel for early diagnosis of pancreatic cancer
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DOI: 10.1002/ijc.34928
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Late presentation of disease at the time of diagnosis is one of the major reasons for dismal prognostic outcomes for PDAC patients. Currently, there is… read more here.
Keywords: panel; early diagnosis; pdac patients; biomarker panel ... See more keywords
Immune-related somatic mutation genes are enriched in PDACs with diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2019.03.006
Abstract: The bidirectional interaction between pancreatic cancer (PanCa) and diabetes has been confirmed by epidemiological studies, but until now, the underlying molecular mechanisms for this connection is not fully understood yet. Here, we analyzed the clinical… read more here.
Keywords: pdac patients; pdacs; somatic mutation; immune related ... See more keywords
Quantitative Metabolomics and Lipoprotein Analysis of PDAC Patients Suggests Serum Marker Categories for Pancreatic Function, Pancreatectomy, Cancer Metabolism, and Systemic Disturbances
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Proteome Research"
DOI: 10.1021/acs.jproteome.3c00611
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is difficult to diagnose in the early stages and lacks reliable biomarkers. The scope of this project was to establish quantitative nuclear magnetic resonance (NMR) spectroscopy to comprehensively study blood serum… read more here.
Keywords: spectroscopy; marker; pdac patients; pancreatic function ... See more keywords
Biliary microbiome profiling via 16 S rRNA amplicon sequencing in patients with cholangiocarcinoma, pancreatic carcinoma and choledocholithiasis
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DOI: 10.1038/s41598-025-00976-6
Abstract: Recent studies have revealed that oral, gut, and intratumoral microbial dysbiosis significantly affects tumor progression, therapy resistance, and prognosis in cholangiocarcinoma (CCA) and pancreatic ductal adenocarcinoma (PDAC) patients. However, the biliary microbiome, which directly interacts… read more here.
Keywords: choledocholithiasis; biliary microbiome; pdac patients; cca pdac ... See more keywords
Surveillance for pancreatic cancer in high-risk individuals leads to improved outcomes: a propensity score-matched analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Gastroenterology"
DOI: 10.1053/j.gastro.2023.02.032
Abstract: BACKGROUND & AIMS Recent pancreatic cancer surveillance programs of high-risk individuals have reported improved outcomes. This study assessed to what extent outcomes of pancreatic ductal adenocarcinoma (PDAC) in patients with a CDKN2A/p16 pathogenic variant (PV)… read more here.
Keywords: surveillance patients; surveillance; pdac patients; non surveillance ... See more keywords
The impact of nutritional status on pancreatic cancer therapy
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DOI: 10.1080/14737140.2022.2026771
Abstract: ABSTRACT Introduction Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive disease with poor outcomes. One of the reasons for the dismal prognosis resides in its impressive ability to alter the nutritional status of patients who develop… read more here.
Keywords: impact nutritional; nutritional status; pdac patients; therapy ... See more keywords
High prevalence of mutant KRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients
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DOI: 10.1093/annonc/mdx004
Abstract: Background Exosomes arise from viable cancer cells and may reflect a different biology than circulating cell-free DNA (cfDNA) shed from dying tissues. We compare exosome-derived DNA (exoDNA) to cfDNA in liquid biopsies of patients with… read more here.
Keywords: pdac patients; mutant kras; early stage; cancer ... See more keywords
Circulating cancer‐associated extracellular vesicles as early detection and recurrence biomarkers for pancreatic cancer
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DOI: 10.1111/cas.15500
Abstract: Early detection of pancreatic ductal adenocarcinoma (PDAC) is essential for improving patient survival rates, and noninvasive biomarkers are urgently required to identify patients who are eligible for curative surgery. Here, we examined extracellular vesicles (EVs)… read more here.
Keywords: extracellular vesicles; pdac patients; recurrence; cancer ... See more keywords
Abstract LB145: Implementing timely germline genetic testing for patients with pancreatic cancer via a point-of-care digital education and health assessment tool
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DOI: 10.1158/1538-7445.am2024-lb145
Abstract: Introduction: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the United States. National guidelines recommend germline genetic testing (GT) for all PDAC patients, but only 6.8-19% obtain GT. Current GT… read more here.
Keywords: cancer; education; tool; pdac patients ... See more keywords
Abstract B117: Phase 1 study of CM24 in combination with nivolumab in patients with advanced pancreatic cancer - Survival, potential biomarker and effect on neutrophil extracellular traps (NETs)
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DOI: 10.1158/1538-7445.panca2023-b117
Abstract: Background: The monoclonal antibody CM24 blocks the activity of carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), which is known to have several important roles in cancer progression, immune evasion, and metastasis. The homophilic interaction of… read more here.
Keywords: ceacam1; cancer; phase study; pdac patients ... See more keywords