Pancreatobiliary-type intraductal papillary mucinous neoplasm of the pancreas may have two subtypes with distinct clinicopathological and genetic features.
Sign Up to like & getrecommendations! Published in 2019 at "Human pathology"
DOI: 10.1016/j.humpath.2019.05.010
Abstract: We recently experienced cases of pancreatobiliary-type intraductal papillary mucinous neoplasms (PB-IPMNs) with imaging features resembling pancreatic ductal adenocarcinomas (PDACs), and histological appearance of purely pancreatobiliary morphology and highly distorted papillary growth, which led to the… read more here.
Keywords: papillary mucinous; pdacs; intraductal papillary; type ... See more keywords
Immune-related somatic mutation genes are enriched in PDACs with diabetes
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DOI: 10.1016/j.tranon.2019.03.006
Abstract: The bidirectional interaction between pancreatic cancer (PanCa) and diabetes has been confirmed by epidemiological studies, but until now, the underlying molecular mechanisms for this connection is not fully understood yet. Here, we analyzed the clinical… read more here.
Keywords: pdac patients; pdacs; somatic mutation; immune related ... See more keywords
Pancreatic ductal adenocarcinomas associated with intraductal papillary mucinous neoplasms (IPMNs) versus pseudo-IPMNs: relative frequency, clinicopathologic characteristics and differential diagnosis
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DOI: 10.1038/s41379-021-00902-x
Abstract: The literature is highly conflicted on what percentage of pancreatic ductal adenocarcinomas (PDACs) arise in association with intraductal papillary mucinous neoplasms (IPMNs). Some studies have claimed that even small (Sendai-negative) IPMNs frequently lead to PDAC.… read more here.
Keywords: pseudo ipmns; pdacs; frequency; pathology ... See more keywords
ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice.
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DOI: 10.1053/j.gastro.2018.03.039
Abstract: BACKGROUND & AIMS The ARID1A gene encodes a protein that is part of the large adenosine triphosphate (ATP)-dependent chromatin remodeling complex SWI/SNF and is frequently mutated in human pancreatic ductal adenocarcinomas (PDACs). We investigated the… read more here.
Keywords: ptf1a cre; cre krasg12d; pdacs; pancreatic ductal ... See more keywords
STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines
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DOI: 10.18632/oncotarget.20833
Abstract: Pancreatic ductal adenocarcinomas (PDACs) are highly aggressive malignancies, associated with poor clinical prognosis and limited therapeutic options. Oncogenic KRAS mutations are found in over 90% of PDACs, playing a central role in tumor progression. Global… read more here.
Keywords: pdac cell; pdacs; cell lines; kinase ... See more keywords