PDCD10 promotes proliferation, migration, and invasion of osteosarcoma by inhibiting apoptosis and activating EMT pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5025
Abstract: Osteosarcoma, a common primary malignant tumor, occurs in children and adolescents with a poor prognosis. The current treatment methods are various, while the five‐year survival rate of patients has not been significantly improved. As a… read more here.
Keywords: proliferation migration; migration invasion; invasion osteosarcoma; pdcd10 ... See more keywords
Loss of programmed cell death 10 activates tumor cells and leads to temozolomide-resistance in glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-03017-7
Abstract: PurposeGlioblastoma (GBM) is one of the most aggressive and incurable primary brain tumors. Identification of novel therapeutic targets is an urgent priority. Programmed cell death 10 (PDCD10), a ubiquitously expressed apoptotic protein, has shown a… read more here.
Keywords: gbm; pdcd10; programmed cell; resistance ... See more keywords
PDCD10-Deficiency Promotes Malignant Behaviors and Tumor Growth via Triggering EphB4 Kinase Activity in Glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01377
Abstract: We previously reported an angiogenic and tumor-suppressor-like function of programmed cell death 10 (PDCD10) in glioblastoma (GBM). However, the underlying mechanism remains to be elucidated. We hypothesized that loss of PDCD10 activates GBM cells and… read more here.
Keywords: ephb4 kinase; gbm; pdcd10; tumor growth ... See more keywords
The Dual Role of PDCD10 in Cancers: A Promising Therapeutic Target
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DOI: 10.3390/cancers14235986
Abstract: Simple Summary As an adaptor protein, PDCD10 is involved in regulation of diverse biological processes by interacting with multiple molecules. Recently, growing amounts of studies have focused on function of PDCD10 in cancers. However, PDCD10… read more here.
Keywords: therapeutic target; pdcd10 cancers; pdcd10; role pdcd10 ... See more keywords
miRNA‑26a‑5p and miR‑26b‑5p inhibit the proliferation of bladder cancer cells by regulating PDCD10.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology reports"
DOI: 10.3892/or.2018.6734
Abstract: MicroRNA (miR)‑26a‑5p and miR‑26b‑5p consistently play an antitumor role in many types of cancers, but the underlying mechanism remains unclear in bladder cancer (BC). In the present study, we found that, in BC tissues, the… read more here.
Keywords: 26a mir; mir 26a; proliferation; pdcd10 ... See more keywords
Non-canonical signaling pathway of SNAI2 induces EMT in ovarian cancer cells by suppressing miR-222-3p transcription and upregulating PDCD10
Sign Up to like & getrecommendations! Published in 2020 at "Theranostics"
DOI: 10.7150/thno.43198
Abstract: Background: Epithelial ovarian cancer (EOC) is one of the most lethal malignancies in women worldwide. Many studies showed the transcription factor SNAI2-induced Epithelial-Mesenchymal Transition (EMT) through inhibiting E-cadherin (E-cad) expression. Our previous study reported that… read more here.
Keywords: mir 222; transcription; snai2; pdcd10 ... See more keywords