MicroRNA miR-212 regulates PDCD4 to attenuate Aβ25–35-induced neurotoxicity via PI3K/AKT signaling pathway in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Letters"
DOI: 10.1007/s10529-020-02915-z
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disease in the elderly. MicroRNA (miRNA) miR-212-3p (miR-212) has been reported to dysregulated in many neurodegenerative diseases including AD. However, the mechanism and function of miR-212 in AD… read more here.
Keywords: pi3k; pdcd4; alzheimer disease; pi3k akt ... See more keywords
LncRNA HOTAIR Promotes LPS-Induced Inflammation and Apoptosis of Cardiomyocytes via Lin28-Mediated PDCD4 Stability.
Sign Up to like & getrecommendations! Published in 2021 at "Inflammation"
DOI: 10.1007/s10753-021-01431-0
Abstract: Sepsis is one of the primary causes of death in intensive care units. Recently, increasing evidence has identified lncRNA HOTAIR is involved in septic cardiomyopathy. However, the potential mechanism underlying HOTAIR on septic cardiomyopathy is… read more here.
Keywords: lps induced; pdcd4; apoptosis; hotair ... See more keywords
Deficiency of programmed cell death 4 affects the balance of T cell subsets in hyperlipidemic mice.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.06.020
Abstract: Programmed cell death 4 (Pdcd4) was found to be related to apoptosis upon first discovery. It was later found to play the role of tumor suppressor gene in a variety of tumors by inhibiting transcription… read more here.
Keywords: hyperlipidemic mice; cell; pdcd4; programmed cell ... See more keywords
Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50672-8
Abstract: Translation is regulated mainly in the initiation step, and its dysregulation is implicated in many human diseases. Several proteins have been found to regulate translational initiation, including Pdcd4 (programmed cell death gene 4). Pdcd4 is… read more here.
Keywords: mrna entry; 40s small; suppressor protein; pdcd4 ... See more keywords
MiR-21 participates in the neuroprotection of diazoxide against hypoxic-ischemia encephalopathy by targeting PDCD4
Sign Up to like & getrecommendations! Published in 2022 at "Brain Injury"
DOI: 10.1080/02699052.2022.2087906
Abstract: ABSTRACT Background Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of neonatal death and permanent neurological disability. Here, we designed to quest therapeutic effects of diazoxide (DZ) on HIE and its mechanism. Methods The… read more here.
Keywords: participates neuroprotection; pi3k akt; mir participates; hie ... See more keywords
LncRNA SLC16A1-AS1 regulates the miR-182/PDCD4 axis and inhibits the triple-negative breast cancer cell cycle.
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and immunotoxicology"
DOI: 10.1080/08923973.2022.2056482
Abstract: PURPOSE Although SLC16A1-AS1 is involved in lung cancer, its function in breast cancer is still elusive. We observed downregulation of SLC16A1-AS1 expression in triple-negative breast cancer (TNBC) by analyzing TCGA dataset. Therefore, we analyzed the… read more here.
Keywords: mir 182; slc16a1 as1; pdcd4; cell ... See more keywords
Absence of nuclear Programmed cell death 4 as an indicator of poor prognosis in uveal melanoma patients
Sign Up to like & getrecommendations! Published in 2017 at "Acta Ophthalmologica"
DOI: 10.1111/j.1755-3768.2017.03643
Abstract: Purpose Uveal melanoma (UM) is the most frequently occurring intraocular malignancy in adults. Arising from the uncontrolled proliferation of melanocytes in the choroid, ciliary body and iris, UMs have a strong propensity to metastasise to… read more here.
Keywords: pdcd4; poor prognosis; uveal melanoma; programmed cell ... See more keywords
MicroRNA (miRNA)-to-miRNA Regulation of Programmed Cell Death 4 (PDCD4)
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00086-19
Abstract: The regulation of tumor suppressor genes by microRNAs (miRNAs) is often demonstrated as a one-miRNA-to-one-target relationship. However, given the large number of miRNA sites within a 3′ untranslated region (UTR), most targets likely undergo miRNA… read more here.
Keywords: cell death; pdcd4; mirna; regulation ... See more keywords
PDCD4 as a marker of mTOR pathway activation and therapeutic target in mycobacterial infections
Sign Up to like & getrecommendations! Published in 2024 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00062-24
Abstract: ABSTRACT Programmed cell death protein 4 (PDCD4) is instrumental in regulating a range of cellular processes such as translation, apoptosis, signal transduction, and inflammatory responses. There is a notable inverse correlation between PDCD4 and the… read more here.
Keywords: pdcd4; activation; mtor; mycobacterial infections ... See more keywords
Abstract 6652: PDCD4/mTORC2 axis regulates tumorigenesis through PFKFB3 in NSCLC
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6652
Abstract: Programmed cell death 4 (PDCD4) is a tumor suppressor whose expression is frequently downregulated in various cancers, including lung cancer. PDCD4 has been shown to suppress tumor cell proliferation, migration, invasion, and metastasis in cultured… read more here.
Keywords: pfkfb3; cancer; pdcd4; pfkfb3 nsclc ... See more keywords
Abstract 4366824: Protection of PDCD4 against doxorubicin-induced cardiotoxicity
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4366824
Abstract: Background: Programmed Cell Death 4 (PDCD4) is a tumor suppressor known for promoting apoptosis and inhibiting growth and protein translation in cancer cells. However, the role of PDCD4 in the heart remains elusive. This study… read more here.
Keywords: role; function; pdcd4; doxorubicin ... See more keywords