MicroRNA miR-212 regulates PDCD4 to attenuate Aβ25–35-induced neurotoxicity via PI3K/AKT signaling pathway in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Letters"
DOI: 10.1007/s10529-020-02915-z
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disease in the elderly. MicroRNA (miRNA) miR-212-3p (miR-212) has been reported to dysregulated in many neurodegenerative diseases including AD. However, the mechanism and function of miR-212 in AD… read more here.
Keywords: pi3k; pdcd4; alzheimer disease; pi3k akt ... See more keywords
LncRNA HOTAIR Promotes LPS-Induced Inflammation and Apoptosis of Cardiomyocytes via Lin28-Mediated PDCD4 Stability.
Sign Up to like & getrecommendations! Published in 2021 at "Inflammation"
DOI: 10.1007/s10753-021-01431-0
Abstract: Sepsis is one of the primary causes of death in intensive care units. Recently, increasing evidence has identified lncRNA HOTAIR is involved in septic cardiomyopathy. However, the potential mechanism underlying HOTAIR on septic cardiomyopathy is… read more here.
Keywords: lps induced; pdcd4; apoptosis; hotair ... See more keywords
Deficiency of programmed cell death 4 affects the balance of T cell subsets in hyperlipidemic mice.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.06.020
Abstract: Programmed cell death 4 (Pdcd4) was found to be related to apoptosis upon first discovery. It was later found to play the role of tumor suppressor gene in a variety of tumors by inhibiting transcription… read more here.
Keywords: hyperlipidemic mice; cell; pdcd4; programmed cell ... See more keywords
MiR-21 participates in the neuroprotection of diazoxide against hypoxic-ischemia encephalopathy by targeting PDCD4
Sign Up to like & getrecommendations! Published in 2022 at "Brain Injury"
DOI: 10.1080/02699052.2022.2087906
Abstract: ABSTRACT Background Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of neonatal death and permanent neurological disability. Here, we designed to quest therapeutic effects of diazoxide (DZ) on HIE and its mechanism. Methods The… read more here.
Keywords: participates neuroprotection; pi3k akt; mir participates; hie ... See more keywords
LncRNA SLC16A1-AS1 regulates the miR-182/PDCD4 axis and inhibits the triple-negative breast cancer cell cycle.
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and immunotoxicology"
DOI: 10.1080/08923973.2022.2056482
Abstract: PURPOSE Although SLC16A1-AS1 is involved in lung cancer, its function in breast cancer is still elusive. We observed downregulation of SLC16A1-AS1 expression in triple-negative breast cancer (TNBC) by analyzing TCGA dataset. Therefore, we analyzed the… read more here.
Keywords: mir 182; slc16a1 as1; pdcd4; cell ... See more keywords
Absence of nuclear Programmed cell death 4 as an indicator of poor prognosis in uveal melanoma patients
Sign Up to like & getrecommendations! Published in 2017 at "Acta Ophthalmologica"
DOI: 10.1111/j.1755-3768.2017.03643
Abstract: Purpose Uveal melanoma (UM) is the most frequently occurring intraocular malignancy in adults. Arising from the uncontrolled proliferation of melanocytes in the choroid, ciliary body and iris, UMs have a strong propensity to metastasise to… read more here.
Keywords: pdcd4; poor prognosis; uveal melanoma; programmed cell ... See more keywords
MicroRNA (miRNA)-to-miRNA Regulation of Programmed Cell Death 4 (PDCD4)
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00086-19
Abstract: The regulation of tumor suppressor genes by microRNAs (miRNAs) is often demonstrated as a one-miRNA-to-one-target relationship. However, given the large number of miRNA sites within a 3′ untranslated region (UTR), most targets likely undergo miRNA… read more here.
Keywords: cell death; pdcd4; mirna; regulation ... See more keywords
A tyrosine kinase-STAT5-miR21-PDCD4 regulatory axis in chronic and acute myeloid leukemia cells.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19192
Abstract: MicroRNAs (miRNAs) are regulators of several key patho-physiological processes, including cell cycle and apoptosis. Using microarray-based miRNA profiling in K562 cells, a model of chronic myeloid leukemia (CML), we found that the oncoprotein BCR-ABL1 regulates… read more here.
Keywords: pdcd4; myeloid leukemia; acute myeloid; leukemia ... See more keywords
Aberrant Expression Of PDCD4/eIF4A1 Signal Predicts Postoperative Recurrence For Early-Stage Oral Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Management and Research"
DOI: 10.2147/cmar.s223273
Abstract: Background Programmed cell death 4 (PDCD4) as a tumor suppressor gene inhibits growth and metastasis of cancer cells, which involved with eIF4A1, the inhibitor of translation initiation. Although the prognosis of early-stage oral squamous cell… read more here.
Keywords: pdcd4; recurrence; early stage; cell ... See more keywords
Long non-coding RNA CASC2 serves as a ceRNA of microRNA-21 to promote PDCD4 expression in oral squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s198970
Abstract: Background: Oral squamous cell carcinoma (OSCC) is a common oral disease with high morbidity and mortality. Recently, long non-coding RNAs (lncRNAs) were identified as critical regulators in OSCC tumorigenesis. The present study aimed to work… read more here.
Keywords: expression; pdcd4; oral squamous; cell ... See more keywords
PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2018.00661
Abstract: While the over-expression of tumor suppressor programmed cell death 4 (PDCD4) induces apoptosis, it was recently shown that PDCD4 knockdown also induced apoptosis. In this study, we examined the cell cycle regulators whose activation is… read more here.
Keywords: pdcd4 knockdown; pdcd4; hepatoma cells; senescence ... See more keywords