Role of phosphodiesterase inhibitors in stent-related symptoms: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Urology"
DOI: 10.1007/s00345-019-02862-z
Abstract: Purpose Stent-related symptoms are frequent following stent placement for various indications. Use of PDE inhibitors has expanded beyond their classical indication and has been tried in patients with stent-related symptoms. The systematic review was conducted… read more here.
Keywords: symptoms systematic; pde inhibitors; stent related; systematic review ... See more keywords
Therapeutic potential of phosphodiesterase inhibitors in the treatment of osteoporosis: scopes for therapeutic repurposing and discovery of new oral osteoanabolic drugs.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174015
Abstract: Cyclic nucleotide phosphodiesterases (PDEs) are ubiquitously expressed enzymes that hydrolyse phosphodiester bond in the second messenger molecules including cAMP and cGMP. A wide range of drugs blocks one or more PDEs thereby preventing the inactivation… read more here.
Keywords: pde inhibitors; treatment; camp cgmp; osteoanabolic drugs ... See more keywords
Influence of Alcohol on Phosphodiesterase 5 inhibitors Use in Middle- to Old-Aged Men: A Comparative Study of Adverse Events
Sign Up to like & getrecommendations! Published in 2019 at "Sexual Medicine"
DOI: 10.1016/j.esxm.2019.07.004
Abstract: Introduction Some previous studies reported recreational use of phosphodiesterase type 5 (PDE-5) inhibitors by ingesting the medicine with alcohol in patients with erectile dysfunction, but the rate of misuse in general population has never been… read more here.
Keywords: use; pde inhibitors; group; concomitant alcohol ... See more keywords
Effects of phosphodiesterase 5 inhibition on cardiovascular function in resistant hypertension: A systematic review.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120270
Abstract: Approximately 12-18% of hypertensive patients are diagnosed with resistant hypertension (RH). The risk of having worse cardiovascular outcomes is twice higher in those patients. The low effectiveness of conventional antihypertensive drugs in RH emphasizes the… read more here.
Keywords: function; hemodynamics; systematic review; resistant hypertension ... See more keywords
Discovery of Novel KRAS-PDEδ Inhibitors by Fragment-Based Drug Design.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00057
Abstract: Targeting KRAS-PDEδ protein-protein interactions with small molecules represents a promising opportunity for developing novel antitumor agents. However, current KRAS-PDEδ inhibitors are limited by poor cellular antitumor potency and the druggability of the target remains to… read more here.
Keywords: pde inhibitors; kras pde; fragment based; drug design ... See more keywords
Sulphonated graphene oxide catalyzed continuous flow synthesis of pyrazolo pyrimidinones, sildenafil and other PDE-5 inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra08220e
Abstract: Sulphonated graphene oxide was used for cascade condensation and cyclization reactions towards accessing substituted pyrazolo pyrimidinones. Further, sulphonation and amination reactions were integrated through continuous flow chemistry to access PDE-5 inhibitors. Herein, we report a… read more here.
Keywords: synthesis; sulphonated graphene; continuous flow; graphene oxide ... See more keywords
Respiratory Cilia as a Therapeutic Target of Phosphodiesterase Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00609
Abstract: Mucociliary clearance is an essential airway defense mechanism dependent predominantly on the proper ciliary function and mucus rheology. The crucial role of cilia is evident in `a variety of respiratory diseases, as the ciliary dysfunction… read more here.
Keywords: pde inhibitors; phosphodiesterase; cilia therapeutic; function ... See more keywords
Use of a Fission Yeast Platform to Identify and Characterize Small Molecule PDE Inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.833156
Abstract: Cyclic nucleotide phosphodiesterases (PDEs) have been proven to be targets for which highly selective and potent drugs can be developed. Mammalian genomes possess 21 genes whose products are pharmacologically grouped into 11 families; however related… read more here.
Keywords: small molecule; pde inhibitors; fission yeast; platform ... See more keywords
Recent developments of phosphodiesterase inhibitors: Clinical trials, emerging indications and novel molecules
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1057083
Abstract: The phosphodiesterase (PDE) enzymes, key regulator of the cyclic nucleotide signal transduction system, are long-established as attractive therapeutic targets. During investigation of trends within clinical trials, we have identified a particularly high number of clinical… read more here.
Keywords: novel molecules; pde inhibitors; clinical trials; development ... See more keywords
ROCK and PDE-5 Inhibitors for the Treatment of Dementia: Literature Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10061348
Abstract: Dementia is a disease in which memory, thought, and behavior-related disorders progress gradually due to brain damage caused by injury or disease. It is mainly caused by Alzheimer’s disease or vascular dementia and several other… read more here.
Keywords: pde inhibitors; meta analysis; disease; analysis ... See more keywords
Determination of Phosphodiesterase Type-5 Inhibitors (PDE-5) in Dietary Supplements
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28104116
Abstract: This study proposed a high-performance thin-layer chromatography (HPTLC) screening method to detect phosphodiesterase 5 (PDE-5) inhibitors as possible adulterant agents in various dietary supplements. Chromatographic analysis was performed on silica gel 60F254 plates using a… read more here.
Keywords: pde inhibitors; phosphodiesterase type; type inhibitors; determination phosphodiesterase ... See more keywords