PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aaw5870
Abstract: PDE1 inhibition enhances the proteasome and protects against proteinopathy and heart failure with preserved ejection fraction. No current treatment targets cardiac proteotoxicity or can reduce mortality of heart failure (HF) with preserved ejection fraction (HFpEF).… read more here.
Keywords: misfolded proteins; degradation misfolded; pde1 inhibition; inhibition ... See more keywords
The Effects of Acute and Chronic Selective Phosphodiesterase 1 Inhibition on Smooth Muscle Cell-Associated Aging Features
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.818355
Abstract: Age-related cardiovascular diseases (CVDs) remain among the leading global causes of death, and vascular smooth muscle cell (VSMC) remodeling plays an essential role in its pathology. Reduced NO-cGMP pathway signaling is a major feature and… read more here.
Keywords: inhibition; muscle cell; pde1 inhibition; treatment ... See more keywords