Structure-Based Design of Scaffolds Targeting PDE10A by INPHARMA-NMR.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00246
Abstract: Phosphodiesterases (PDE) hydrolyze both cyclic AMP and GMP (cAMP/cGMP) and are responsible for the regulation of their levels in a multitude of cellular functions. PDE10A is expressed in the brain and is a validated target… read more here.
Keywords: inpharma nmr; pde10a; structure based; inpharma ... See more keywords
Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbac181
Abstract: Abstract Background and hypothesis Phosphodiesterase 10A (PDE10A) is a highly expressed enzyme in the basal ganglia, where cortical glutamatergic and midbrain dopaminergic inputs are integrated. Therapeutic PDE10A inhibition effects on schizophrenia have been reported previously,… read more here.
Keywords: phosphodiesterase 10a; positron emission; patients schizophrenia; bpnd ... See more keywords
PDE10A Inactivation Prevents Doxorubicin-Induced Cardiotoxicity and Tumor Growth.
Sign Up to like & getrecommendations! Published in 2023 at "Circulation research"
DOI: 10.1161/circresaha.122.322264
Abstract: BACKGROUND Cyclic nucleotides play critical roles in cardiovascular biology and disease. PDE10A (phosphodiesterase 10A) is able to hydrolyze both cAMP and cGMP. PDE10A expression is induced in various human tumor cell lines, and PDE10A inhibition… read more here.
Keywords: induced cardiotoxicity; growth; dox; cardiotoxicity ... See more keywords
Response by Chen and Yan to Letter Regarding Article, "A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction".
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circulationaha.120.048259
Abstract: Circulation. 2020;142:e36–e37. DOI: 10.1161/CIRCULATIONAHA.120.048259 e36 Si Chen, MS Chen Yan, PhD In Response: We appreciate Wang et al for their interest in our recent publication1 and their comments regarding the potential impact of noncardiac PDE10A… read more here.
Keywords: pde10a; chen; role; response ... See more keywords