PDE2 at the crossway between cAMP and cGMP signalling in the heart.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.06.020
Abstract: The cyclic nucleotides cAMP and cGMP are central second messengers in cardiac cells and critical regulators of cardiac physiology as well as pathophysiology. Consequently, subcellular compartmentalization allows for spatiotemporal control of cAMP/cGMP metabolism and subsequent… read more here.
Keywords: heart; camp; cgmp signalling; camp cgmp ... See more keywords
Abstract 576: Phosphodiesterase 2 in Cardiac Arrhythmias and Heart Failure
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.576
Abstract: Heart failure (HF) patients often suffer from lethal ventricular arrhythmias leading to sudden cardiac arrests. Phosphodiesterase 2 (PDE2), a cGMP activated enzyme hydrolyzing cAMP, is upregulated in HF. Cardiac-specific PDE2 overexpression revealed strong anti-arrhythmic and… read more here.
Keywords: cnp; heart; specific pde2; heart failure ... See more keywords