Drotaverine Inhibitor of PDE4: Reverses the Streptozotocin Induced Alzheimer's Disease in Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03327-9
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with decline in memory and cognitive impairments. Phosphodiesterase IV (PDE4) protein, an intracellular cAMP levels regulator, when inhibited act as potent neuroprotective agents by virtue of… read more here.
Keywords: inhibitor; alzheimer disease; drotaverine; group ... See more keywords
Structure-Based Optimization of Moracin M as Potent and Selective PDE4 Inhibitors with Antipsoriasis Effects.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c00266
Abstract: Psoriasis is a complex chronic inflammatory disease that severely affects the quality of life of patients. However, current medications could only control the symptoms but not cure psoriasis with unmet medical needs. Herein, structure-based optimizations… read more here.
Keywords: structure based; pde4; structure; based optimization ... See more keywords
PDE4 subtypes in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1258-8
Abstract: Cyclic nucleotide phosphodiesterases (PDE) break down cyclic nucleotides such as cAMP and cGMP, reducing the signaling of these important intracellular second messengers. Several unique families of phosphodiesterases exist, and certain families are clinically important modulators… read more here.
Keywords: cancer; pde4; subtypes cancer; pde4 subtypes ... See more keywords
Phosphodiesterase type 4 inhibition enhances nitric oxide- and hydrogen sulfide-mediated bladder neck inhibitory neurotransmission
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22934-1
Abstract: Nitric oxide (NO) and hydrogen sulfide (H2S) play a pivotal role in nerve-mediated relaxation of the bladder outflow region. In the bladder neck, a marked phosphodiesterase type 4 (PDE4) expression has also been described and… read more here.
Keywords: inhibitory neurotransmission; neck; nitric oxide; bladder neck ... See more keywords
Structural insight into selective phosphodiesterase 4B inhibitors: pharmacophore-based virtual screening, docking, and molecular dynamics simulations
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2016.1183520
Abstract: Phosphodiesterase (PDE4) is the predominantly expressing family of PDE enzyme in immune and inflammatory cells. Inhibition of PDE4 has been reported to suppress a diverse spectrum of inflammatory responses both in vitro and in vivo.… read more here.
Keywords: analysis; pde4b; pde4d; structure ... See more keywords
Pharmacology of orismilast, a potent and selective PDE4 inhibitor
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.18818
Abstract: There remains an unmet need for oral medications that are safe and efficacious for long‐term management of chronic inflammatory skin diseases (CISD). Inhibition of phosphodiesterase 4 (PDE4) can modulate a broad range of pro‐inflammatory cytokines… read more here.
Keywords: pharmacology; pharmacology orismilast; orismilast potent; pde4 ... See more keywords
Serum Interleukin-8 as a Determinant of Response to PDE4 Inhibition in Chronic Obstructive Pulmonary Disease.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.202301-0071oc
Abstract: RATIONALE Phosphodiesterase-4 inhibitors (PDE4i) have demonstrated increased efficacy in COPD patients with chronic bronchitis or higher blood eosinophil counts. Further characterization of patients most likely to benefit is warranted. OBJECTIVE To identify determinants of response… read more here.
Keywords: pde4 inhibition; serum interleukin; response pde4; pde4 ... See more keywords
Regulation of cAMP accumulation and activity by distinct phosphodiesterase subtypes in INS-1 cells and human pancreatic β-cells
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0215188
Abstract: Pancreatic β-cells express multiple phosphodiesterase (PDE) subtypes, but the specific roles for each in β-cell function, particularly in humans, is not clear. We evaluated the cellular role of PDE1, PDE3, and PDE4 activity in the… read more here.
Keywords: camp levels; camp; inhibition; pancreatic cells ... See more keywords
Phosphodiesterase 4 (PDE4) gene expression in atopic dermatitis patients, before and after treatment with topical mometasone cream
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Dermatology"
DOI: 10.1684/ejd.2022.4194
Abstract: Background Atopic dermatitis (AD) is a chronic pruritic inflammatory dermatosis. Phosphodiesterases (PDEs) are a superfamily of enzymes that catalyse the hydrolysis of cyclic AMP (cAMP), a second messenger that controls key cellular functions, into its… read more here.
Keywords: pde4 gene; gene expression; atopic dermatitis; treatment ... See more keywords
Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db21-0898
Abstract: Patients with type 2 diabetes have a substantial risk of developing cardiovascular disease. Phosphodiesterase 4 (PDE4) dysregulation is of pathophysiological importance in metabolic disorders. To determine the role of PDE4 in diabetic cardiac dysfunction, mice… read more here.
Keywords: inhibition; roflumilast; expression; dysfunction ... See more keywords
The multifaceted role of phosphodiesterase 4 in tumor: from tumorigenesis to immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1528932
Abstract: Phosphodiesterase 4 (PDE4) is an enzyme that specifically hydrolyzes the second messenger cAMP and has a critical role in the regulation of a variety of cellular functions. In recent years, PDE4 has attracted great interest… read more here.
Keywords: pde4; role; immunotherapy; phosphodiesterase ... See more keywords