Serum Interleukin-8 as a Determinant of Response to PDE4 Inhibition in Chronic Obstructive Pulmonary Disease.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.202301-0071oc
Abstract: RATIONALE Phosphodiesterase-4 inhibitors (PDE4i) have demonstrated increased efficacy in COPD patients with chronic bronchitis or higher blood eosinophil counts. Further characterization of patients most likely to benefit is warranted. OBJECTIVE To identify determinants of response… read more here.
Keywords: pde4 inhibition; serum interleukin; response pde4; pde4 ... See more keywords
Non-Selective PDE4 Inhibition Induces a Rapid and Transient Decrease of Serum Potassium in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11111582
Abstract: Simple Summary Inhibitors of phosphodiesterase 4 (PDE4), a group of isoenzymes that hydrolyze and inactivate the second messenger cAMP, produce promising therapeutic benefits, including anti-inflammatory and memory-enhancing effects. Here, we report that, unexpectedly, PDE4 inhibitors… read more here.
Keywords: pde4 inhibitors; potassium; pde4 inhibition; potassium levels ... See more keywords