Scouting in silico different chemo-types of PDE4 inhibitors to guide the design of new anti-inflammatory/antioxidant agents.
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300046
Abstract: During the last years, we developed a large library of new selective phosphodiesterase 4D inhibitors, maintaining the catechol portion of the well-known PDE4 inhibitor Rolipram, featuring different substitutions in place of the lactam group of… read more here.
Keywords: pde4 inhibitors; scouting silico; anti inflammatory; silico different ... See more keywords
Inhaled Phosphodiesterase 4 (PDE4) Inhibitors for Inflammatory Respiratory Diseases
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DOI: 10.3389/fphar.2020.00259
Abstract: PDE4 inhibitors can suppress a variety of inflammatory cell functions that contribute to their anti-inflammatory actions in respiratory diseases like chronic obstructive pulmonary disease (COPD) and asthma. The systemically delivered PDE4 inhibitor roflumilast has been… read more here.
Keywords: phosphodiesterase pde4; pde4 inhibitors; respiratory diseases; pde4 ... See more keywords
Non-Selective PDE4 Inhibition Induces a Rapid and Transient Decrease of Serum Potassium in Mice
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DOI: 10.3390/biology11111582
Abstract: Simple Summary Inhibitors of phosphodiesterase 4 (PDE4), a group of isoenzymes that hydrolyze and inactivate the second messenger cAMP, produce promising therapeutic benefits, including anti-inflammatory and memory-enhancing effects. Here, we report that, unexpectedly, PDE4 inhibitors… read more here.
Keywords: pde4 inhibitors; potassium; pde4 inhibition; potassium levels ... See more keywords
An Overview of PDE4 Inhibitors in Clinical Trials: 2010 to Early 2022
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DOI: 10.3390/molecules27154964
Abstract: Since the early 1980s, phosphodiesterase 4 (PDE4) has been an attractive target for the treatment of inflammation-based diseases. Several scientific advancements, by both academia and pharmaceutical companies, have enabled the identification of many synthetic ligands… read more here.
Keywords: pde4 inhibitors; 2010 early; overview pde4; clinical trials ... See more keywords