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Published in 2023 at "Molecular informatics"
DOI: 10.1002/minf.202200214
Abstract: The aim of the study was to develop AutoML models to search for novel MTDL chemotypes blocking PDE4B, PDE8A, and TRPA1. Asthma and COPD are characterized by complex pathophysiology associated with chronic inflammation, bronchoconstriction, and…
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Keywords:
pde4b pde8a;
asthma copd;
blocking pde4b;
pde4b ... See more keywords
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Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114132
Abstract: Acute kidney injury (AKI), characterized by a rapid decline in renal function, is triggered by an acute inflammatory response that leads to kidney damage. An effective treatment for AKI is lacking. Using in vitro and…
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Keywords:
cpd;
kidney injury;
cisplatin;
acute kidney ... See more keywords
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Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2018.08.008
Abstract: OBJECTIVES To investigate the functional role of miR-23a in synovial fibroblasts (SFC) activation in psoriatic arthritis (PsA). METHODS Differential expression of the miR-23a-27a-24-2 cluster was identified by real-time quantitative PCR in PsA synovial tissue and…
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Keywords:
psoriatic arthritis;
psa sfc;
pde4b;
expression ... See more keywords
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Published in 2018 at "Journal of Molecular and Cellular Cardiology"
DOI: 10.1016/j.yjmcc.2018.05.121
Abstract: The ubiquitous second messenger 3',5'-cyclic Adenosine Monophosphate (cAMP) regulates the cardiac Excitation-Contraction Coupling (ECC) by acting in discrete subcellular microdomains. Phosphodiesterase (PDE) subfamilies 4B and 4D are critically involved in the regulation of cAMP signaling…
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Keywords:
die;
camp;
pde4b;
der ... See more keywords
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Published in 2017 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2016.1183520
Abstract: Phosphodiesterase (PDE4) is the predominantly expressing family of PDE enzyme in immune and inflammatory cells. Inhibition of PDE4 has been reported to suppress a diverse spectrum of inflammatory responses both in vitro and in vivo.…
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Keywords:
analysis;
pde4b;
pde4d;
structure ... See more keywords
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Published in 2023 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2023.2183496
Abstract: ABSTRACT Introduction Phosphodiesterase 4B (PDE4B) is a crucial enzyme in the phosphodiesterases (PDEs), acting as a regulator of cyclic adenosine monophosphate (cAMP). It is involved in cancer process through PDE4B/cAMP signaling pathway. Cancer occurs and…
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Keywords:
cancer;
pde4b;
advances phosphodiesterase;
phosphodiesterase cancer ... See more keywords
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Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.783050
Abstract: Urinary bladder cancer (UBC) is a common malignant tumor with high incidence. Advances in the diagnosis and treatment of this disease demand the identification of novel therapeutic targets. Multiple studies demonstrated that PDE4B level was…
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Keywords:
cancer;
mesenchymal transition;
pde4b;
bladder cancer ... See more keywords
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Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.01582
Abstract: Natural products are considered an important source of bioactive compounds especially in biodiversity-rich countries like Brazil. The identification of potential targets is crucial to the development of drugs from natural sources. In this context, in…
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Keywords:
bryophyllum pinnatum;
quercetin arabinopyranosyl;
target;
pde4b ... See more keywords