Phosphodiesterases 4B and 4D Differentially Regulate cAMP Signaling in Calcium Handling Microdomains of Adult Mouse Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular and Cellular Cardiology"
DOI: 10.1016/j.yjmcc.2018.05.121
Abstract: The ubiquitous second messenger 3',5'-cyclic Adenosine Monophosphate (cAMP) regulates the cardiac Excitation-Contraction Coupling (ECC) by acting in discrete subcellular microdomains. Phosphodiesterase (PDE) subfamilies 4B and 4D are critically involved in the regulation of cAMP signaling… read more here.
Keywords: die; camp; pde4b; der ... See more keywords
Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00193
Abstract: Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory domain, known as UCR2, that opens and closes over the… read more here.
Keywords: design synthesis; fragile syndrome; allosteric inhibitors; pde4d ... See more keywords
PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.469
Abstract: The cyclic AMP (cAMP) signaling pathway is critical in melanocyte biology for regulating differentiation. It is downregulated by phosphodiesterase (PDE) enzymes, which degrade cAMP itself. In melanoma evidence suggests that inhibition of the cAMP pathway… read more here.
Keywords: invasion; braf mutated; cell invasion; pde4d ... See more keywords
Structural insight into selective phosphodiesterase 4B inhibitors: pharmacophore-based virtual screening, docking, and molecular dynamics simulations
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2016.1183520
Abstract: Phosphodiesterase (PDE4) is the predominantly expressing family of PDE enzyme in immune and inflammatory cells. Inhibition of PDE4 has been reported to suppress a diverse spectrum of inflammatory responses both in vitro and in vivo.… read more here.
Keywords: analysis; pde4b; pde4d; structure ... See more keywords
PDE4B and PDE4D differentially regulate cardiac pacemaker activity
Sign Up to like & getrecommendations! Published in 2021 at "Europace"
DOI: 10.1093/europace/euab116.570
Abstract: Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Agence Nationale de la Recherche (ANR) Background Heart rate (HR) is generated by spontaneous electrical activity in the sinoatrial node (SAN) and is… read more here.
Keywords: mice; pacemaker activity; activity; pde4bko pde4dko ... See more keywords
Insight into Inhibitory Mechanism of PDE4D by Dietary Polyphenols Using Molecular Dynamics Simulations and Free Energy Calculations
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11030479
Abstract: Phosphodiesterase 4 (PDE4), mainly present in immune, epithelial, and brain cells, represents a family of key enzymes for the degradation of cyclic adenosine monophosphate (cAMP), which modulates inflammatory response. In recent years, the inhibition of… read more here.
Keywords: energy calculations; molecular dynamics; pde4d; free energy ... See more keywords