PDE5 inhibitor sildenafil attenuates cardiac microRNA 214 upregulation and pro-apoptotic signaling after chronic alcohol ingestion in mice
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03779-7
Abstract: Abusive chronic alcohol consumption can cause metabolic and functional derangements in the heart and is a risk factor for development of non-ischemic cardiomyopathy. microRNA 214 (miR-214) is a molecular sensor of stress signals that negatively… read more here.
Keywords: pde5 inhibitor; microrna 214; sildenafil; mir 214 ... See more keywords
New Approaches in Oncology for Repositioning Drugs: The Case of PDE5 Inhibitor Sildenafil
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.627229
Abstract: The use of already-approved drugs to treat new or alternative diseases has proved to be beneficial in medicine, because it reduces both drug development costs and timelines. Most drugs can be used to treat different… read more here.
Keywords: pde5 inhibitor; pde5 inhibitors; pde5; case ... See more keywords