Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104322
Abstract: Celecoxib, is a selective cyclooxygenase-2 (COX2) inhibitor with a 1,5-diaryl pyrazole scaffold. Celecoxib has a better safety profile compared to other COX2 inhibitors having side effects of systemic hypertension and thromboembolic complications. This may be… read more here.
Keywords: pyrazolines novel; pde5 inhibitors; pde5; discovery trisubstituted ... See more keywords
Phosphodiesterase 5 inhibitors as novel agents for the treatment of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2019.09.001
Abstract: Alzheimer's disease (AD), characterized by a progressive impairment of memory and cognition, is a major health problem in both developing and developed countries. Currently, no drugs can reverse the progression of AD. Phosphodiesterase 5 (PDE5)… read more here.
Keywords: pde5 inhibitors; alzheimer disease; treatment; disease ... See more keywords
The two phases of the clinical validation of preclinical translational mechanistic research on PDE5 inhibitors since Viagra’s advent. A personal perspective
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Impotence Research"
DOI: 10.1038/s41443-018-0076-9
Abstract: The FDA approval of Viagra (sildenafil) for the on demand treatment of erectile dysfunction (ED) through relaxation of the corporal and cavernosal vascular smooth muscle that results in an increase in blood flow to the… read more here.
Keywords: viagra; research; clinical validation; pde5 inhibitors ... See more keywords
Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17028-4
Abstract: Phosphodiesterase-5 (PDE5) inhibitors are suggested to have anti-tumor effects and to inhibit surgery-induced immunosuppression. We aimed to explore whether post-diagnostic use of PDE5 inhibitors was associated with a better prognosis among male patients with colorectal cancer… read more here.
Keywords: risk; pde5 inhibitors; mortality; phosphodiesterase ... See more keywords
A Comprehensive Review on Analytical Techniques for Determination of Sex Stimulants, PDE5 Inhibitors in Different Matrices with Special Focus on the Electroanalytical Methods.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in analytical chemistry"
DOI: 10.1080/10408347.2022.2152274
Abstract: Erectile dysfunction (ED) is one of the most common chronic diseases affecting men and its incidence increases with aging. Due to its substantial influence on the quality of life, phosphodiesterase type-5 (PDE5) inhibitors have been… read more here.
Keywords: analytical techniques; review; pde5 inhibitors; determination ... See more keywords
Efficacy and safety of PDE5 inhibitors in the treatment of diabetes mellitus erectile dysfunction: Protocol for a systematic review: Erratum
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000013203
Abstract: In the article, “Efficacy and safety of PDE5 inhibitors in the treatment of diabetes mellitus erectile dysfunction: Protocol for a systematic review”, which appeared in Volume 97, Issue 40 of Medicine, the footnote should read:… read more here.
Keywords: medicine; pde5 inhibitors; safety pde5; efficacy safety ... See more keywords
Testicular toxicity following separate and combined administration of PDE5 inhibitors and opioid: assessment of recovery following their withdrawal
Sign Up to like & getrecommendations! Published in 2017 at "Andrologia"
DOI: 10.1111/and.12669
Abstract: We previously observed that PDE5 inhibitors and opioids were widely abused in Nigeria. Here, we examined the effect of high doses of sildenafil, tadalafil, tramadol and sildenafil + tramadol on reproductive toxicity in male rats.… read more here.
Keywords: recovery; pde5 inhibitors; tramadol; toxicity ... See more keywords
Assessment of the intracavernosal injection platelet‐rich plasma in addition to daily oral tadalafil intake in diabetic patients with erectile dysfunction non‐responding to on‐demand oral PDE5 inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14421
Abstract: This study aimed to evaluate the effectiveness of ICI of platelet‐rich plasma (PRP) in addition to daily oral tadalafil intake in diabetic erectile dysfunction (ED) patients non‐responding to PDE5 inhibitors. Overall, 48 patients complaining of… read more here.
Keywords: responding demand; platelet rich; rich plasma; pde5 inhibitors ... See more keywords
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-040122-034745
Abstract: Cyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically… read more here.
Keywords: toxicology; pharmacology; cgmp; erectile dysfunction ... See more keywords
New Approaches in Oncology for Repositioning Drugs: The Case of PDE5 Inhibitor Sildenafil
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.627229
Abstract: The use of already-approved drugs to treat new or alternative diseases has proved to be beneficial in medicine, because it reduces both drug development costs and timelines. Most drugs can be used to treat different… read more here.
Keywords: pde5 inhibitor; pde5 inhibitors; pde5; case ... See more keywords