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   Articles with "pde5a" as a keyword



#2303 PDE5 inhibitor LW1646 improves kidney fibrosis by alleviating ER stress and mitochondrial calcium overload

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recommendations! Published in 2025 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaf116.1363

Abstract: Renal fibrosis is the terminal pathological manifestation of most chronic kidney diseases (CKDs). Inhibitors targeting phosphodiesterase 5 (PDE5) have been used to treat erectile dysfunction and pulmonary arterial hypertension by increasing cGMP levels and activating… read more here.

Keywords: fibrosis; renal fibrosis; pde5a; stress ... See more keywords

LncRNA ARAP1-AS1 targets miR-516b-5p/PDE5A axis to facilitate the progression of thyroid cancer

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recommendations! Published in 2022 at "Anti-Cancer Drugs"

DOI: 10.1097/cad.0000000000001438

Abstract: Thyroid cancer (TC) remains a prevalent public health concern. To further study the molecular mechanism of TC development, we explored the regulatory mechanism and function of lncRNA ARAP1-AS1 in TC progression. The verification of ARAP1-AS1,… read more here.

Keywords: pde5a; cancer; arap1 as1; mir 516b ... See more keywords
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Abstract 232: PDE5A Inhibition in Burn-induced Cardiac Dysfunction

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recommendations! Published in 2020 at "Circulation Research"

DOI: 10.1161/res.127.suppl_1.232

Abstract: Severe burn injury initiates a feedback cycle of inflammation, fibrosis and oxidative stress and others that may contribute to heart dysfunction via the PDE5A-cGMP-PKG pathway. Sildenafil (SIL) has been shown decrease immune adverse events in… read more here.

Keywords: pde5a; burn; heart; dysfunction ... See more keywords

A label-free LC/MS-based enzymatic activity assay for the detection of PDE5A inhibitors

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recommendations! Published in 2023 at "Frontiers in Chemistry"

DOI: 10.3389/fchem.2023.1097027

Abstract: Phosphodiesterase type 5 (PDE5), a cyclic nucleotide phosphodiesterase, controls the duration of the cyclic guanosine monophosphate (cGMP) signal by hydrolyzing cGMP to GMP. Inhibiting the activity of PDE5A has proven to be an effective strategy… read more here.

Keywords: activity assay; pde5a inhibitors; activity; based enzymatic ... See more keywords

Phosphodiesterase 5a Signalling in Skeletal Muscle Pathophysiology

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24010703

Abstract: Phosphodiesterase 5A (PDE5A) is involved in cGMP hydrolysis, regulating many physiological processes. Increased activity of PDE5A has been found in several pathological conditions, and the pharmacological inhibition of PDE5 has been demonstrated to have several… read more here.

Keywords: phosphodiesterase signalling; muscle; pde5a; pde5a isoforms ... See more keywords