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Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001438
Abstract: Thyroid cancer (TC) remains a prevalent public health concern. To further study the molecular mechanism of TC development, we explored the regulatory mechanism and function of lncRNA ARAP1-AS1 in TC progression. The verification of ARAP1-AS1,…
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Keywords:
pde5a;
cancer;
arap1 as1;
mir 516b ... See more keywords
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Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.232
Abstract: Severe burn injury initiates a feedback cycle of inflammation, fibrosis and oxidative stress and others that may contribute to heart dysfunction via the PDE5A-cGMP-PKG pathway. Sildenafil (SIL) has been shown decrease immune adverse events in…
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Keywords:
pde5a;
burn;
heart;
dysfunction ... See more keywords
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Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1097027
Abstract: Phosphodiesterase type 5 (PDE5), a cyclic nucleotide phosphodiesterase, controls the duration of the cyclic guanosine monophosphate (cGMP) signal by hydrolyzing cGMP to GMP. Inhibiting the activity of PDE5A has proven to be an effective strategy…
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Keywords:
activity assay;
pde5a inhibitors;
activity;
based enzymatic ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010703
Abstract: Phosphodiesterase 5A (PDE5A) is involved in cGMP hydrolysis, regulating many physiological processes. Increased activity of PDE5A has been found in several pathological conditions, and the pharmacological inhibition of PDE5 has been demonstrated to have several…
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Keywords:
phosphodiesterase signalling;
muscle;
pde5a;
pde5a isoforms ... See more keywords