A label-free LC/MS-based enzymatic activity assay for the detection of PDE5A inhibitors
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DOI: 10.3389/fchem.2023.1097027
Abstract: Phosphodiesterase type 5 (PDE5), a cyclic nucleotide phosphodiesterase, controls the duration of the cyclic guanosine monophosphate (cGMP) signal by hydrolyzing cGMP to GMP. Inhibiting the activity of PDE5A has proven to be an effective strategy… read more here.
Keywords: activity assay; pde5a inhibitors; activity; based enzymatic ... See more keywords